New Schizophrenia Drug Cuts Down on Side Effects

“The compound itself is quite novel in that it does not bind either dopamine D1 or D2 receptors and it also doesn’t bind to serotonin 2A 5-HT2A receptors,” Kent said. "So, all of the currently marketed antipsychotics target either D1, D2 or both and 5HT2A.”


Along with some improvements across a broad array of symptoms, the investigators found patients taking SEP-363856 in the trial significantly improved functionally as well.

Patients treated with SEP-363856 demonstrated clinically meaningful improvements in the Positive and Negative Syndrome Scale (PANSS) total score (-22.6), the Clinical Global Impression Scale-Severity (CGI-S) score (-1.0), as well as the Brief Negative Symptom Scale (BNSS) total score (-11.3).

Sounds good!