“The compound itself is quite novel in that it does not bind either dopamine D1 or D2 receptors and it also doesn’t bind to serotonin 2A 5-HT2A receptors,” Kent said. "So, all of the currently marketed antipsychotics target either D1, D2 or both and 5HT2A.”
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Along with some improvements across a broad array of symptoms, the investigators found patients taking SEP-363856 in the trial significantly improved functionally as well.
Patients treated with SEP-363856 demonstrated clinically meaningful improvements in the Positive and Negative Syndrome Scale (PANSS) total score (-22.6), the Clinical Global Impression Scale-Severity (CGI-S) score (-1.0), as well as the Brief Negative Symptom Scale (BNSS) total score (-11.3).
Sounds good!
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