https://www.psychiatrictimes.com/depression/new-hope-depression-horizon
Unlike other available antidepressants, it is believed the SNDRI class of medications will be relatively beneficial in preserving patients’ sexual functions. Data also suggests SNDRIs will have a better safety profile, produce a more rapid onset, and provide better efficacy.1
Anything which improves working memory automatically reduces depression, negative symptoms. Certain brain training games which target working memory also useful like dual n back.
Thanks. It is really promising, i take an mao-inhibitor, which releases the same transporters (serotonin, noradrenaline and dopamine), i’m very pleased with the efficacy, but it’s a difficult and complicated drug to take, due to interactions with certain food and other meds.
They compare MAO vs. SNDRI this way:
“It is believed that, compared with monoamine transporters, their broader spectrum inhibition would lead to enhanced efficacy and faster antidepressant response while also addressing a broader range of symptoms (including anhedonia).”