Neanderthal-derived genetic variation in living humans relates to schizophrenia diagnosis, to psychotic symptom severity, and to dopamine synthesis

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I suppose the obvious follow up question would be whether subsaharian Africans (who never interbred with neanderthals) and out-of-Africa humans (which did interbreed) display any significant differences on sz rates and prognosis.

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Try Fred Previc’s book, “the dopaminergic mind in human evolution and history”. Very interesting for this topic.

If possible check it out from a library. It gets scientific at times, but was an enjoyable read.

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I found this part quite perplexing.

First, in four independent case-control datasets totaling 9,362 individuals, individuals with schizophrenia had less Neanderthal-derived genetic variation

So technically, we are genetically more normal than most people. Or am I not reading that right?

Genetically more “modern”, I believe. Sz is a disease of the times, more prevalent in the developed world.

Technology and dopamine hits go together like PB&J.

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I got a lot of neanderthal snps.

Interesting read. I’ve thought about that before. Schizophrenia and Neanderthal DNA.