Mind mapper: MIT's new tech shows whole brain hemispheres in 3D detail

[TheLogician]

Mind mapper: MIT's new tech shows whole brain hemispheres in 3D detail

Bing:

• MIT’s Breakthrough: A suite of three technological innovations has enabled the mapping of whole hemispheres of the human brain1.
• High-Resolution 3D Imaging: The technology allows for high-resolution, high-throughput imaging of human brain tissue2.
• Subcellular Detail: It provides detailed views from the gross morphological level to subcellular components3.
• Holistic Analysis: The technique offers a holistic analysis of the brain, maintaining the integrity of the full hemispheres2.
• Comparison of Brains: The system was demonstrated by comparing brain regions from two donors, one with Alzheimer’s and one without2.
• Potential Applications: This could provide unprecedented insights into brain cognition and disease pathogenesis2.
• Challenges Overcome: Previously, imaging at subcellular resolution was not possible without slicing the brain due to its thickness4.
• Team Effort: The project was led by Kwanghun Chung and involved three talented young scientists4.

[Nirvana]

It’s good to see this type of news. Awesome, thanks for sharing!

[TheLogician]

I posted these two articles a couple weeks ago without them getting much attention.

Study uncovers cell type-specific genetic insights underlying schizophrenia

https://medicalxpress.com/news/2024-05-uncovers-cell-specific-genetic-insights.amp brain. “We discovered which cell types express genes associated with schizophrenia risk differently, which biological functions are impacted within those cells, and which transcription factors are important for these changes,” explained lead and co-corresponding author, W. Brad Ruzicka MD, Ph.D., director of the Laboratory for Epigenomics in Human Psychopathology at McLean Hospital. “This understanding will allow future treatments to be tailored to specific genes and cell types, as well as individuals with schizophrenia.” Through transcriptomic analysis, two distinct subpopulations of individuals with schiz…

Two studies offer key insights into the origins and potential treatment of mental health disorders

https://medicalxpress.com/news/2024-05-key-insights-potential-treatment-mental.amp These investigations, conducted with colleagues from other major research centers, involve the largest single-cell analysis to date of the brains of people with schizophrenia, and a first-of-its-kind population-scale map of the regulatory components of the brain that provides critical insights into the pathogenesis of mental health disorders. “We desperately need new directions for developing treatments for individuals with schizophrenia and other serious mental health illnesses,” says Panos Roussos, MD, Ph.D., senior author of both studies; Professor of Psychiatry, and Genetics and Genomic Sciences, at the …

From what I made of them there pretty big news.
I think one of them even suggests a target for crispr / gene therapy specifically for schizophrenia.