Maoi B vs Maoi A for anhedonia

For anhedonia is a Maoi B a better option rather than a maoi A for anhedonia as it has more dopamine. I was going to ask for Parnate but I do not think it is a Maoi B. Thanks.

Tranylcypromine (Parnate) is slightly selective for MAO-B, but it works on MAO-A too, and already at low doses, which is in contrast to selective MAOIs such as selegiline and rasagiline which are highly selective for MAO-B, and moclobemide which is selective for MAO-A. Tranylcypromine also has an intrinsic amphetamine-like effect; ie. it causes the release of dopamine. For anhedonia, of the clinically available MAOIs, I would certainly go with tranylcypromine.


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Dont antipsychotics block dopamine to prevent psychosis? How is it good to boost dopamine then?


It is good for anhedonia. That was the question. Perhaps I should have mentioned that it may worsen psychosis, in some people even trigger it.


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