Kynurenine pathway abnormalities are state-specific but not diagnosis-specific in schizophrenia and bipolar disorder

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In “Brain, Behavior & Immunity”, in open access:

# Kynurenine pathway abnormalities are state-specific but not diagnosis-specific in schizophrenia and bipolar disorder

Highlights

• Schizophrenia and bipolar disorder are characterized by lower serum kynurenine metabolite concentrations.

• Serum kynurenine metabolite aberrances are a transdiagnostic feature of bipolar and schizophrenic patients.

• Quinaldic acid is an important state marker for psychotic symptoms.

• Duration of illness mostly impacts xanthurenic and quinolinic acid abnormalities.

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It’s curious that quinaldic acid doesn’t even have a Wikipedia page, at this advanced day of 2023.