A very small (57 patients, 33 control persons) study of mitochondrial function in schizophrenia. Published recently in Schizophrenia Research.
Patients with SZ exhibited higher elevation of lactate than HCs during exercise but not at baseline or at rest. In accordance, patients showed higher number of CAMDs and lower mtDNA copy number. Interestingly, CAMDs correlated with both lactate levels and mtDNA copy number, which in turn correlated with the NLR. Finally, we identified 13 putative pathogenic variants in the mtDNA of 11 participants with SZ not present in HCs, together with a lactate elevation during exercise that was significantly higher in these 11 carriers than in the noncarriers.
Um is this implying us sz should not exercise?
I’m confused. Com!
The study is very small, and I think that mitochondrial dysfuction, if it is indeed present, must be present in only a subset of patients. Moreover, it is mild, because lactate only rises during exercise. This is my guess. I hope there will be larger studies, and I’m not competent to say whether it’s good or bad to exercise for patients.
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Yea I have read about exercise increasing oxidative stress which causes damage.
However, in turn the body toughens up.
Perhaps that is the case here but idk
There is another study in the same journal that says that exercise may be good in schizophrenia:
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As far as I know, long-distance running increases one’s lactate threshold, which means that your muscles start to produce a lot of lactate later into the run. Thus it may be actually good to exercise. But the human body is very complex, and I guess there will never be a one-fit-all answer.
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Yehh true
I have a concern I might have aneurysms idk if I shud b exercising with that kind of condition. Cos u know increased blood pressure, more force on the blood vessel walls kinda thing.
The period time during which the person practices running or linguistic expression in an organized and coherent context,it is considered the most important natural antidote to blocking the sz pathogen activity in the conscious mind / emotion during waking time
It works on the regularity of the coherence / harmony between the sensory processes with mental and motor for a period of time,which completely loss and it is impossible to create any harmony during the period of stillness of movement
The head of the problem is mainly related to 'who is uses the body energy for his interest ?
the person himself or the sz pathogen ?
the pathogen (hallucination) aims all time of waking to release the energy to carry out its operations in the conscious mind / emotion of the person
In other expression,the functional activity of any process performed by the pathogen it result in the release of an amount of electrochemical energy that is dispersed during emotional / mental reactions ( reflex reactions)
Therefore,running sports exercise frees up energy in the direction of the running process only and this in itself prevent (block) the pathogen from using the energy to carry out its operations in the person’s mind /emotion
I downloaded the actual article and a couple other articles on mitochondrial clues to SZ, and it’s all very complicated. I would not give any advice to patients based on these studies. There are many, many factors that may affect these mitochondrial parameters, and this subfield of study is still quite young. So thus far I think that exercise is good. Let reseachers wrangle it out between themselves for 10 more years, maybe they will come up to some more solid conclusion.
Can you be a little clearer, are you saying this lactate stuff could “point you in the right direction” like how exercise works?
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