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Tracing Early Neurodevelopment in Schizophrenia with Induced Pluropotent Stem Cells Ruhel Ahmad, Vincenza Sportelli … and Anke Hoffmann. Page 9 of secition 1.5.4 Oxidative Stress dives into it.
This was a topic of great controversy with my parents. I have my father treating his multiple sclerosis with it and he suggested I undergo treatment for my sz. My concern was that the new pathways I would form would worsen my symptoms. Ive reluctantly done two treatments in the last three years. I have noticed a huge spike in congitive abilities and have had combatted the resurfacing and stronger symptoms with neuroplasticity training exercises. Overall Im much better symptom wise and have a greater capacity for learning
https://my.clevelandclinic.org/health/diseases/15612-mitochondrial-diseases/management-and-treatment
Treatments for mitochondrial disease may include:
- Vitamins and supplements , including Coenzyme Q10; B complex vitamins, especially thiamine (B1) and riboflavin (B2); Alpha lipoic acid; L-carnitine (Carnitor); Creatine; and L-Arginine.
- Exercises , including both endurance exercises and resistance/strength training. These are done to increase muscle size and strength. Endurance exercises include walking, running, swimming, dancing, cycling and others. Resistance/strength training include exercises such as sit-ups, arm curls, knee extensions, weight lifting and others.
- Conserving energy . Don’t try to do too much in a short period of time. Pace yourself.
- Other treatments . These may include speech therapy, physical therapy, respiratory therapy, and occupational therapy.
Avoid situations that can make your medical condition worse. These include: exposure to cold and/or heat; starvation; lack of sleep; stressful situations; and use of alcohol, cigarettes and monosodium glutamate (MSG, a flavor enhancer commonly added to Chinese food, canned vegetables, soups, and processed meats).
Note: I was originally suspected of mitochondrial disease.
Mitochondrial disease can be fatal for those who have it. I had months of seizures and thought I was going to die. But later I was diagnosed with a different condition which is also genetic.
BACKGROUND:
Mitochondrial dysfunction and an elevation of lactate are observed in patients with schizophrenia (SZ). However, it is unknown whether mitochondrial dysfunction is associated with the presence of mitochondrial DNA (mtDNA) alterations and comorbid clinical conditions. We aimed to identify systemic mitochondrial abnormalities in blood samples of patients with SZ that may have a high impact on the brain due to its high bioenergetic requirements.
METHODS:
Case/control study between 57 patients with SZ and 33 healthy controls (HCs). We measured lactate levels at baseline, during 15 min of exercise (at 5, 10 and 15 min) and at rest. We also evaluated the presence of clinical conditions associated with mitochondrial disorders (CAMDs), measured the neutrophil to lymphocyte ratio (NLR, a subclinical inflammatory marker), and analyzed mtDNA variation and copy number.
RESULTS:
Linear models adjusting for covariates showed that patients with SZ exhibited higher elevation of lactate than HCs during exercise but not at baseline or at rest. In accordance, patients showed higher number of CAMDs and lower mtDNA copy number. Interestingly, CAMDs correlated with both lactate levels and mtDNA copy number, which in turn correlated with the NLR. Finally, we identified 13 putative pathogenic variants in the mtDNA of 11 participants with SZ not present in HCs, together with a lactate elevation during exercise that was significantly higher in these 11 carriers than in the noncarriers.
CONCLUSIONS:
These results are consistent with systemic mitochondrial malfunctioning in SZ and pinpoint lactate metabolism and mtDNA as targets for potential therapeutic treatments.