How does APs makes us gain weight?

In my case i have an increase of appetite i eat more… Idk any studies or links regarding this. Your thoughts are welcome here :slight_smile:

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Calling :phone: @firemonkey with links

https://www.bap.org.uk/articles/antipsychotic-medication-and-weight-gain/

https://www.hopkinsmedicine.org/news/media/releases/Hopkins_Scientists_Uncover_Cause_Of_Antipsychotic_Drug_Weight_Gain

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Yes at night I have to stop eating to lose weight

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Thank you @firemonkey i read them all

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The AP’s slow down your metabolism some, and the AP’s increase your appetite some, and the combination is deadly. When I was on Zyprexa I craved sugar - badly. I gained 60 lbs. in 120 days. I don’t know how I did that. In order to gain that much body fat I would have had to have a calorie excess of 1750 calories a day. I know I didn’t gain that much muscle, and I know I didn’t have that much excess water in my system. I have no idea how I gained that much weight.

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I lost 50 pounds while taking three different AP drugs. And I’ve kept it all off over the last three years by counting my calories on a calorie counting app. And most important: I never eat less than 1100 calories a day. This is very important. If you eat less than 1100 calories a day, you go into starvation mode and then you start packing on the pounds. The app will tell you what your maximum calories for the day will be. I use the calorie counting app: MyFitnessPal.com It has the largest food data base in the world, making calorie counting a snap. I also never drink my calories, meaning no pop, juices, energy drinks, fancy coffees, or alcohol. And I exercise for a half hour everyday doing something that I love doing. My personal choices are yoga and piano practice. Yours can be anything you like that will lead to fitness.

I am at ideal body weight today and have been for the past three years.

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I wish I could say that. I’m about eighty pounds overweight.

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@crimby Why not try my methods?

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I have my compulsions. I would rather try to lose weight through exercise.

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My theory is APs lower dopamine, resulting in appetite increase. Food increases dopamine in the brain.

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We learned in our pharmacology class that the chemistry behind it is their blockade of serotonin. (APs bind to serotonin receptors as well as dopamine) I know on a larger level they affect appetite and also fat storage, so maybe the serotonin blockade results in this. Meds with a higher serotonin receptor binding profile cause more weight gain.

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Increased appetite, cant get full, decreased metabolism, and lack of physical activity from slowed down movements and drive.

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It baffles me honestly. I have to consume 1000 to 1500 calories a day to feel like im not starving and burn at least 700 to lose water weight. I carry alot of water weight now compared to before i got on meds. I even use to eat more before i got on meds. For me it mainly slowed my metabolism down by a whole lot. Im about as active now as i was before the meds so its definately the slowed metabolism. If i consume 1500 calories in one day without exercise ill gain a pretty good amount of weight. My pdoc doesnt even care neither. If i was working i would be screwed weight wise cause id be too tired to exercise after work

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Things I have heard why APs cause weight gain (don’t know the evidence behind them)

  • increase appetite
  • decrease metabolism
  • increase appetite for carbohydrates and influence the insulin based metabolism of them
  • sedation and negative symptoms can reduce the patients physical activity
  • effect the leptin based fat homeostasis system
  • change the commensal flora in the gut to a weight promoting flora profile
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I am disappointed that so many health professionals (from doctors, nurses to dietitians) seem to think it is solely down to increased appetite and refuse to believe otherwise.

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I am so frustrated. I gained 5lbs this month. I am now 5’5 203lbs. The invega sustenna is getting on my last nerve. I don’t know what to do. I have just given up.

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How long did it take to lose the weight? Congratulations!

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Let me guess they dont want to switch meds bcus it works for positives right? Cause thats what my pdocs say

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Wow. Thank you. I notice I eat more junk food while on meds. I seem to make more poor eating choices.

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