Hope for drug discovery in schizophrenia

http://www.diagnosticsworldnews.com/2018/10/26/nature-study-brings-new-hope-for-drug-discovery-in-schizophrenia-other-diseases.aspx

Researchers prepared a series of assays from each individual’s cells, treated them with 135 different small molecules selected for their predicted or demonstrated interaction with schizophrenia-relevant biology, and analyzed gene activity. The same drugs were tested on commonly used cancer cell lines for comparison. Results showed that the patient-derived cells yielded more disease-relevant information than the generic cells. In some cases, certain drugs reversed the gene expression signatures associated with schizophrenia.

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In the case,if you have seek to treatment the schizophrenia as a disease.
You will need to manufacturing a specific antipsychotic be working as an antagonist to a psychic parasite (external factor)

  • you must change your paradigm,because all current antipsychotics have effect on the biochemistry of the brain ,for this reason you can not achieve actual recovery form the schizophrenia
  • The real hope in the next generation of scientists who they can understanding my notion

Individuals diagnosed with schizophrenia differ greatly from one another. Researchers have demonstrated that very few identical brain differences are shared amongst different patients. Therefore, insights based on research at the group level (i.e. in the ‘average’ patient) say little about the individual.

Radboud University Medical Center. (2018, October 10). Recognizing the uniqueness of different individuals with schizophrenia: Research reveals large differences between individual patients. ScienceDaily . Retrieved November 24, 2018 from www.sciencedaily.com/releases/2018/10/181010132415.htm

It is understood that,the current researchers when they speaking about a health condition be called “schizophrenia”,they are talking about a group of difference symptoms,independent ,

  • whereas each single symptom separated about all others symptoms,
  • all diagnosed symptoms have not causality relationship with any corporeal cause

In principle,the researchers do not know the essential nature of the condition be named by “schizophrenia”,add for that they do not know the existential cause or the functional cause who is responses for producing all types of the diagnosed symptoms ,and they do not know the mechanism of effect

In sums,they are talking,dealing with and treating different diagnosed symptoms rather than a specific whole condition “united condition”

All studying of researchers have seek to find a causality linkage between the diagnosed symptoms and the biological background (they do that while they have not enough accurate information about the nature of the mother condition, the existential cause,the functional cause and the mechanism of effect )

They focus their interesting on the genes,mutations,chemical substances,the chemical functions,the anatomical changes and the different effect of medical drugs on the biochemistry of the brain ,on the consideration that this is the possible biological factors for the symptoms of (sz) !
(remember,they do not know what is schizophrenia condition in itself)

Just,they assume a theoretical causes for diagnosed symptoms that producing by activity of unknown condition regard with them .
1-they do not know what schizophrenia is in itself,then they have not idea what is cause
2- they can diagnosis the symptoms,so that they can assume a different/contrary theoretical causes for these symptoms on the hope that they can treatment them by medication and achieve the final recovery !
3- in reality,there is no real treatment to the schizophrenia condition itself,but there is an endless attempts to treatment a diagnosed symptoms by medication
4- the current medication have blocking/obstruction the mental chemistry of the brain for some degree
5-the current medication have not any effect on the sz condition,the existential cause,the functional cause or mechanism of effect ,so that the condition will remain for lifetime without elimination by effectiveness of all current medication !

I agree that a sample size of 12 is not enough to generalize about the gene expression of all people with schizophrenia. However that they can do it for any person is pretty cool. It might be that bespoke therapies are necessary, or that you might be able to make a drug that would work for 10% of schizophrenics, but you’d know which 10% up front.

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The overconfidence in the genetic science “biological faith” make the scientists belief blindly that the schizophrenia condition must be a genetic disease produced by defective genetic functions for gene/genes,and the schizophrenia is chemical disorder no matter its essential nature .
The gene creates the human being life ,the behaviors ,the disease conditions and the healthy conditions,the psyche entity,the conscious mind,the thoughts …etc everything/anything

All of this was happened ,although they can not diagnosis the symptoms by lab means,the disease substance or the gene who is responses for producing the schizophrenia condition/symptoms !
Form 50 years ago until now they remain belief that sz condition is a genetic disease without finding any human gene,instead they focus the attention towards the existence of sz conditions in the family members or relatives to prove the credibility of their belief !
what is the gene who makes the schizophrenia an inherited condition for family member generation?
What is the gene who is transmission the Sz condition between the generations of single family ?

In all cases,they considering the sz condition a genetic disease according to blindly belief issue in the genetic science -no matter the nature of schizophrenia condition !

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So basically you are saying there’s a parasite in the brain that has psychic powers and/or you’re trying to say a parasitic human/alien with psychic powers is f***ing with ones mind and that one that suffers is now called schizophrenic? And as long as that “psychic parasite” is not removed from the brain or in ones real life there is no cure? Which one is it?

Please… in case you respond… respond in a understandable matter instead of disorganized/explanations thoughts glued together.

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@panoramic20, I find it interesting what you write, but it’s difficult to understand you.

Indeed, it’s really disorganized therefore I only can read a part or half of what he’s saying… Let him respond to my question… it’s clear enough to not make a whole “bookwork” about it.

I understood some stuff.

He says scientists can’t understand the existential cause of schizophrenia, so they get attached to biological issues like brain chemistry (dopaminergic theory).

The medications have no effect on the existential cause of schizophrenia, so people with it will never heal if they keep with this paradigm that schizophrenia is just about biological causes.

An existential cause is very subjective and personal for each person.

He said “essential cause”, not “existential cause”.

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He said “existential cause”, @Moonbeam.

I agree partially though… I think/know everyone has there’s angels and demons but is not schizophrenic.
I’ve basically healed from schizophrenia 3 times but never from the “parasites” left in me the first time.

For example, I can take no matter how much medication I’m prescribed/want, I however keep the “demon” that was ones placed into me (if you know what I mean).

I think what he’s trying to say is that one will not recover unless that/those “demons” is replaced by “angels”…

Sorta of what the Hindustani’s believe… It’s not called schizophrenia over there but rather a message from “familiar” angels or demons. And that there’s no cure for in it in any case…

idk if that makes sense :joy::sweat_smile:

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Ah, you’re correct. I was looking at his second post where he mentioned “essential nature”

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Lol :joy: I didn’t take what you mean, but if demons are kind like our past traumas, maybe it makes sense.

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hahaha yeah it’s fcking confusing… anyway… Let’s wait and respect @panoramic20 opinion. AFAIK my first question is quite simple to answer… :slight_smile:

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English is obviously not his first language. But I’m used to interpreting.

No hes not saying that at all Youngschizo. Parasite external factor means like an outside unseen unknown entity that is like a collective mind. More or less that it cant be found because we are looking in the wrong place. I.e genetics.

Young
Basically,
1-I do not say there’s a parasite in the brain that has psychic powers or else.
2-I do not say there’s a parasitic human/alien with psychic powers is fighting with ones mind

In the case you are able to understand only the meaning of words that I will write .
1-Schizophrenia is a living health condition of inhuman creature (s) ,it is not a symptoms of genetic disease or mental illness,it is living creature (s) not a disease in nature .
-If you see,hear ,touch and coexistence with the sz health condition directly by your self,you will perceive that it is a whole psychological entity (s), in principle it is something like yourself
-Schizophrenia seems her/himself inside the internal psychological world of the human being as a living features of a psychic entity (s) inhuman in nature
-Schizophrenia health condition is independent in structure/function about Both the biological healthy condition and the psychological healthy condition of the human being
-Schizophrenia health condition is not rooted from the genetic functions or the mental processes
-The human being with sz have 3 health conditions in the same time,biological and psychological healthy conditions ( united altogether) beside independent schizophrenia health condition (visitor)

Before using the word “parasite” in the text, do you understand my words ?

Why you understand what I said,while most of others have no idea about the subject ?
Yes, for sz there is an Existential cause (it is not a gene )and a Functional cause “it is not chemical”
In the mother nature of sz,both the existential cause and functional are Single thing (united),so that without elimination the existential cause by medication the sz condition will remain existent in the psychological life and the characteristics of the functional cause can be working at any time - regardless the disappearing of the chemical imbalance features by medication (4 weeks) or retraction the mental disorders (long time)

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