Here’s some info on it
Forskolin is a unique activator of adenylate cyclase that bypasses membrane receptors and directly raised levels of the second messenger cyclic AMP. Depressed patients and schizophrenic patients with negative symptoms have been reported to have reduced cyclic AMP levels. In the first study of forskolin in psychiatry, we gave iv forskolin in a 75 minute infusion to four depressed and five schizophrenic patients. All four depressed patients showed a transient mood elevation or stimulation, as did two of the five schizophrenic patients.
https://www.nature.com/articles/s41598-024-66025-w
Forskolin reverses the O-GlcNAcylation dependent decrease in GABAAR current amplitude at hippocampal synapses possibly at a neurosteroid site on GABAARs
- Objective: Investigate how forskolin affects GABAergic transmission under conditions of heightened O-GlcNAcylation.
- Background:
- GABAARs (Gamma-aminobutyric acid type A receptors) are crucial for synaptic and tonic inhibition.
- O-GlcNAcylation is a post-translational modification that can impact GABAAR function.
- Key Findings:
- Forskolin reverses the decrease in GABAAR current amplitude caused by increased O-GlcNAcylation.
- This reversal is not dependent on serine phosphorylation.
- Heightened O-GlcNAcylation makes the neurosteroid site on GABAARs accessible to agonists, enhancing synaptic inhibition.
- Methods:
- Pharmacological increase of O-GlcNAcylation and subsequent forskolin application.
- Recording of inhibitory postsynaptic currents (IPSCs) from hippocampal principal cells.
- Implications:
- Understanding the interaction between O-GlcNAcylation and forskolin could provide insights into modulating GABAergic transmission.
- Potential therapeutic implications for neuropsychiatric disorders linked to GABAAR dysfunction.
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