Genes, environment and schizophrenia: new study finds the placenta is the missing link

From Firemonkey Today:

Hiding in plain sight, new research shines a spotlight on the placenta’s critical role in the nature versus nurture debate and how it confers risk for schizophrenia and likely other neurodevelopmental disorders including ADHD, autism, and Tourette syndrome. This new scientific frontier, with far-reaching implications for maternal and child health, creates the possibility that scientists can more accurately predict who is at risk of mental illness, and develop strategies to prevent or lessen their occurrence by increasing the resiliency and health of the placenta.

The study, “Convergence of placenta biology and genetic risk for schizophrenia,” was led by researchers at the Lieber Institute for Brain Development and published in Nature Medicine. “For the first time, we have found an explanation for the connection between early life complications, genetic risk, and their impact on mental illness and it all converges on the placenta,” said Daniel R. Weinberger, who led the team of investigators on the study and is CEO of the Lieber Institute for Brain Development (LIBD).

In contrast to prior studies that focused on how genes related to behavioral disorders directly alter prenatal brain development, this novel research found that many genes associated with risk for schizophrenia appear to alter early brain development indirectly, by influencing the health of the placenta. The research showed that these genes are “turned on” in the placenta during complicated pregnancies and signal a placenta under duress.

2 Likes

We want cure…!!! We are already suffering… want to know which gene causes sz…!!

Part of the puzzle. We are in the ball park and moving in to the better seats from the cheap ones!

Technology is our answer and I’m excited for the future sufferers by our gains in understanding. Might come a bit late for me but that is ok!

2 Likes

It was minutes after they took I from the bottomless pit. During my growth in the womb and during birth they do things to us.

I’m possessed, it’s negative, being thrown into solstice for the rituals and to gather solar power front my body has filled the intentionally placed hole at center of my brain with the lifeform\forms known as light.

Yes all, they do things to you in the womb and place holes in your mind by dosing you at birth. If you acquire a large dose of light, although it is paiful as ■■■■, it heals it although if it weren’t for the hoarding of sciences and materials there would be painless means of healing it.

The doctors thought I might get down syndrome. I wonder if they did a blood test. My mom said she didn’t care.

Interesting information. I suspect any cures derived from this will arrive too late for most of us here except for the very young’uns.

it levees me with more ? dna changing is cool but if its sub structure isn’t a vires then its ratified by a element.