GABAergic inhibitory neurons as therapeutic targets for cognitive impairment in schizophrenia

https://www.ncbi.nlm.nih.gov/m/pubmed/29565038

Recent research suggests that selective modulation of the GABAergic system is a promising intervention for the treatment of schizophrenia-associated cognitive defects. In this review, we summarized evidence from postmortem and animal studies for abnormal GABAergic neurotransmission in schizophrenia, and how altered GABA interneurons could disrupt neuronal oscillations. Next, we systemically reviewed a variety of up-to-date subtype-selective agonists, antagonists, positive and negative allosteric modulators (including dual allosteric modulators) for α5/α3/α2 GABAA and GABAB receptors, and summarized their pro-cognitive effects in animal behavioral tests and clinical trials. Finally, we also discuss various representative histone deacetylases (HDAC) inhibitors that target GABA system through epigenetic modulations, GABA prodrug and presynaptic GABA transporter inhibitors. This review provides important information on current potential GABA-associated therapies and future insights for development of more effective treatments.

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Just out of interest, why didn’t you do a proper headline?
It would be easier to get the gist of the content that way.

Edit: I see that it was done.

Some sites let you paste a link in the topic line and it does the work for you… other times it doesn’t.

Actually the technology is pretty nifty.

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This is very interesting but it’s paywalled. :disappointed:

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