G6PD deficiency in brain induces schizophrenia-like behaviors and synaptic dysfunction

https://www.nature.com/articles/s41398-025-03631-w

While clinical investigations have proposed a link between G6PD deficiency and schizophrenia, the underlying biological mechanisms remain unestablished. We here demonstrate that brain-specific G6PD knockout induces schizophrenia-like behaviors in mice, establishing a direct association between G6PD deficiency and schizophrenia. Proteomic analysis revealed aberrant synaptic protein expression in the knockout mice.

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Lol there is so much information. Should have asked a sz nic like me from where did I get it. It was a choice I made. Nothing more nothing less. I got it because I am gifted :heart_eyes:

And all of you are.

With the right meds you can overcome normal people more over exceed them. Only thing is some times I am wrong. Because I have to be. Else who will prove me wrong :person_shrugging::wink:

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How are you @everhopeful hoping all is lovely :rose:

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Doing ok today, thanks @Mentality

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What’s schizophrenia-like behaviors? Like screaming at your neighbors?

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It’s nice research is progressing, I hope we are able to benefit with reductions in stigma

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I stil want 2 come off my meds but im so torn if i shud or shud not. Daaaaaaam. It cud go soooo bad or soooo good.

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