Rat brains point to lead's role in schizophrenia

A study of the brains of rats exposed to lead has uncovered striking similarities with what is known about the brains of human schizophrenia patients, adding compelling evidence that lead is a factor in the onset of schizophrenia.

Results of the study by scientists at Columbia University’s Mailman School of Public Health appear in the journal Translational Psychiatry.

The researchers found that lead had a detrimental effect on cells in three brain areas implicated in schizophrenia: the medial prefrontal cortex, the hippocampus, and the striatum of rats exposed to lead before birth and in the early part of their lives. Density of brain cells known as Parvalbumin-Positive GABAergic interneurons, or PVGI, declined by approximately a third–at roughly the same percentage decline seen in schizophrenia patients. And, using imaging technology, they identified higher levels of a dopamine receptor called D2R. Again, the magnitude of the increase matched what has been documented in human schizophrenia patients, and in a previous study of genetically engineered mice.

“The similarities in the brain structure and neuronal systems between what we see in lead-exposed rats and human schizophrenia patients are striking, and adds to a growing body of literature suggesting that early lead exposure primes the brain for schizophrenia later in life,” says senior author Tomás Guilarte, PhD, chair of Environmental Health Sciences at the Mailman School.

1 Like

2015 and they have only just discovered this. What the do these researches do with all there time?

Man if firemonkey actually reads all this then… Well he’s a master of sz knowledge.

I’m not a master of anything except maybe excavating my own navel fluff.

A pubmed search for schizophrenia “lead exposure” brought up 9 hits, 7 of which there was an abstract available. The earliest one was from 2004.

http://www.ncbi.nlm.nih.gov/pubmed/?term=schizophrenia+"lead+exposure"

1 Like

Still man your plugging away. Be it at your nasal cavities or sz studies. If nominate you king. I wonder what the king of sz.com would even do?

There are no Kings or queens here. We all have something of value to contribute. Perhaps if there was a King he would turn back the clouds.

1 Like