Above my pay grade but interesting.
“Enhancing NMDA receptor function in schizophrenia reverses a cognitive deficit associated with underactivation of the superior temporal gyrus (117) and with EEG deficits seen in mismatch negativity paradigms (118).”
Right. I definitely need my superior temporal gyrus to be activated. Without question. Which meds activate temporal gyrus???
Too big for me but I thought that the drugs they were developing with the glutamate reglulation had problems. It was big for a while there but kinda went away. I’m not on top of medical research though.
The only thing I can think to point to in response to that is something like this
https://www.sciencedirect.com/topics/medicine-and-dentistry/glutamate-decarboxylase-67
Maybe it’s not the amount of glutamate. Maybe its that glutamate isn’t metabolizing into GABA. Idk.
Yeah 2013. My point. From what I understood the drugs they were developing had serious problems like siezures. It was a while ago but it was all over the boards a whiles ago.
An amazing article. Too bad, I’ll probably be dead when they finally cure schizophrenia.
Sarcosine is an agonist to glyt1 receptor. I think that is glutamatergic.