Examining the potential preventative effects of minocycline prescribed for acne on the incidence of severe mental illnesses: A historical cohort study

firemonkey · December 8, 2017, 12:27pm

ncbi.nlm.nih.gov

Examining the potential preventative effects of minocycline prescribed for acne on the incidence of severe mental illnesses: A historical cohort study.

M Herrero-Zazo, R Brauer, F Gaughran, LM Howard, D Taylor and DJ Barlow, Journal of psychopharmacology (Oxford, England), Dec 2017 01

Animal studies suggest that the antibiotic and microglial activation inhibitor, minocycline, is likely to have a protective effect against the emergence of psychosis but evidence from human studies is lacking. The aim of this study is to examine the effects of exposure to minocycline during adolescence on the later incidence of severe mental illness (SMI).A historical cohort study using electronic primary care data was conducted to assess the association between exposure to minocycline during adolescence and incidence of SMI. The Incidence Rate Ratio (IRR) was measured using Poisson regression adjusted for age, gender, time of exposure, socioeconomic deprivation status, calendar year and co-medications.Early minocycline prescription ( n=13,248) did not affect the incidence of SMI compared with non-prescription of minocycline ( n=14,393), regardless of gender or whether or not the data were filtered according to a minimum exposure period (minimum period: IRR 0.96; 95% CI 0.68-1.36; p=0.821; no minimum period: IRR 1.08; 95% CI 0.83-1.42; p=0.566).Exposure to minocycline for acne treatment during adolescence appears to have no effect on the incidence of SMI.

InnerCircle · December 8, 2017, 8:14pm

From my reading, minocycline has been found empirically to help many schizophrenics with their negative symptoms - the apathy and withdrawal that are often so painful for themselves and those who love them. It can’t hurt for patients to ask their treating psychiatrist whether this is worth a try.

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Examining the potential preventative effects of minocycline prescribed for acne on the incidence of severe mental illnesses: A historical cohort study

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