Effectiveness of KarXT (xanomeline-trospium) for cognitive impairment in schizophrenia: post hoc analyses from a randomised, double-blind, placebo-controlled phase 2 study

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This is truely amazing! This article, published in a very reliable journal, shows that the reduction in the negative score of PANSS seems almost exclusively be caused by cognitive impovement. In the other article on this phase 2 study of KarXT, there was a -3 improvement of negative PANSS in 5 weeks, with the chart going straight down and seeming to continue like that after 5 weeks. Note that there is only one cognitive test in the negative PANSS and it has a value between 1 and 7, so we see an improvement by half of the score in 5 weeks!

The phase 3 clinical trial NCT04820309 on clinicaltrials has completion date already next year, July 2023.

Based on these results, I hope KarXT will be designated breakthrough therapy.

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(The reduction may be even greater because in this article, they say you should ignore those patients without cognitive impairment at all.)

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Welcome to the forum @anon50054372 !

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@jeroenp . Good News …Couple Of Years In Europe …

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I read somewhere else that the want to submit a New Drug Application in mid-2023. I hope it will become available in the US within the next 2 or 3 years.

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I have Lyme disease unfortunately too once that is out of my body, my schizophrenic symptoms resolve 100%, many of you people might have it too, some not due to other psychosis, I rest my case…

You are not going to tel lme psychosis cause pains in brain, inflamation (in some), and body, depression, not responding to clozapine an only to anti biotics that is well researched like minocycline, I herx pretty bad on minocycline well enough to say dangerous, I take LDN 1,5 mg for lyme and thats the only thing I am taking to fight it to feel a little better this is week 5…

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I wonder when this drug will be approved

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@Nirvana I think the company is hoping for 1st or 2nd quarter of 2024, if everything goes well.
They have to complete trial(s), analyze (and publish) results, prepare application, and wait 9+ months for FDA to approve or reject it.
Sometimes the companies under estimate how long the process will take.

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@robertc So quickly! That would be great!

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