SY Chen, F Wen, CB Zhao, DM Zhang and XL Wu,
Zhonghua yi xue za zhi, Feb 2020 11
Objective: To clarify the effect of cognitive impairment on social function and quality of life of chronic schizophrenia, and provide clinical cognitive strategies for improving the social function and quality of life of patients with schizophrenia. Methods: Atotal of 158 patients with chronic schizophrenia were selected from May 2017 to October 2017 in the Psychiatry Department of the Third Affiliated Hospital of Sun Yat-sen University received psychological assessments, such as, MATRICS Consensus Cognitive Battery(MCCB), the Brief Psychiatric Rating Scale(BPRS), the Personal and Social Performance scale(PSP), and Schizophrenia Quality of Life Scale(SQLS). We further explored the effects of neurocognitive and social cognitive functions on their individual and social performance and quality of life in patients with schizophrenia. Results: (1) The scores of SQLS in the group with impaired social cognitive function were higher than those with good social function(101±46 vs 76±40, P=0.002). (2) The digital sequence and continuous performance test of the socially functional group were higher than the defect group. (3) There was a significant correlation between the years of education(R(2)=0.334, F=25.542), continuous performance (R(2)=0.316, F=35.647), BPRS (R(2)=0.280, F=60.386) and social function (P<0.001). (4) BPRS (R(2)=0.486, F=228.28), and emotional management (MSCEIT) (R(2)=0.510, F=124.789), education (R(2)=0.531, F=90.161), age (R(2)=0.539, F=69.644) significantly affected the SQLS score of patients with schizophrenia(P<0.001). Conclusion: The social function and quality of life of patients with schizophrenia are significantly correlated with their years of education and disease severity. Continuous performance in neurocognition significantly affects the social function of patients with schizophrenia, and emotional management in social cognition significantly affects their quality of life. Socially functional schizophrenia patients have higher digital sequences (working memory) and continuous performance (attention/alertness) scores.目的： 阐明认知功能缺陷对慢性精神分裂症患者社会功能及生活质量的影响，为改善精神分裂症患者社会功能和生活质量提供临床认知应对策略。 方法： 选择2017年5月至10月在中山大学附属第三医院精神心理科门诊就诊的158例慢性精神分裂症患者，进行MATRICS共识认知成套测试（MCCB）、简明精神病评定量表（BPRS）、个人和社会功能量表（PSP）、精神分裂症生活质量量表（SQLS）评估，探索精神分裂症患者认知功能对其社会功能和生活质量的影响。 结果： （1）社会认知功能低下组的SQLS得分高于社会功能良好组[（101±46）分比（76±40）分，P=0.002]，差异有统计学意义；（2）社会功能良好组的数字序列和持续操作得分高于缺陷组，差异具有统计学意义；（3）受教育年限（R(2)=0.334，F=25.542）、持续操作（R(2)=0.316，F=35.647）、病情严重度（BPRS）（R(2)=0.280，F=60.386）与患者社会功能（PSP）的存在具有显著相关性（均P<0.001）；（4）病情严重度（BPRS）（R(2)=0.486，F=228.28）、情绪管理（R(2)=0.510，F=124.789）、受教育年限（R(2)=0.531，F=90.161）、年龄（R(2)=0.539，F=69.644）显著影响慢性精神分裂症患者的SQLS总分（均P<0.001）。 结论： 精神分裂症患者社会功能和生活质量与其受教育年限、疾病严重程度显著相关，神经认知中的持续操作显著影响精神分裂症患者的社会功能，社会认知中的情绪管理因子显著影响其生活质量；社会功能良好的精神分裂症患者拥有更高的数字序列（工作记忆）和持续操作（注意/警觉性）得分。.