Do you think you could actually handle it if your negative symptoms went away?

DX'd - Sz/SzA
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Like if Min-101 makes it to market and works as advertised for example.

I’m not sure I could unless it happened really really slowly. Suddenly having drives and desires but with cognitive defects could be a disaster. Or would it ? :thinking:

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My negative symptoms went away with memantine. I’m studying to college entrance examination and looking for a job.

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Wait, what? According to google

Memantine is used to treat moderate to severe Alzheimer’s disease

How did you get put on that? Can you explain more about the effect it had?

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Of course.

I read about a research made with memantine here in the forum. I handled the research to my pdoc. We agreed to use the medicine for the neg symptoms as off-label. The med just worked 15 days later.

I read this article: New Meta-Study: Memantine May Help as an add-on to antipsychotic treatment for residual negative and cognitive symptoms of schizophrenia

I even sent a message to @SzAdmin thanking him for the article.

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The only thing I could ever do is make music. It doesn’t seem I have negative symptoms when it comes to making music, but I have it towards everything else.

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If min101 really is effective, the improvement WILL be slow, I am not worried about that aspect. Imagine there was a pill that suppressed negatives instantly… and if you skipped a dose you’d be back to square one lol :smile: emotional yoyo.

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Maybe you should read about memantine. It took my negative symptoms away in 15 days (I mean, the whole improvement took around 4 months, but in 15 days I felt a huge difference).

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Did you suffer anhedonia or flat affect before memantine? These are my problems now.

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Hahaha I DREAM that my problems will go away !
I wish it!
I salivate over it!

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I suffered with flat affect, but not with anhedonia.

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I’m going to keep memantine in mind. Thanks. If you don’t mind me asking, what antipsychotic are you on?

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I’m on 20mg of aripiprazole (Aristab here in Brazil). I’m also taking 20mg of memantine, but I felt a huge effect with just 10mg.

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Next year I may change my pdoc. I am lookinfg for someone more open minded. And maybe I will try memantine…

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I’m on aripiprazole too, 15mg. Thanks again.

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You’re welcome :blush:!

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Thank you for sharing. Would you mind to share what your negative symptoms were like before Memantine? If not, no worries.

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I remember that my negative symptoms were so strong that I wouldn’t answer people here on the forum. But with a lot of therapy I handled it and started to talk to people with no problems here on the forum.

Before memantine I would feel very afraid of going to Pilates for example. I didn’t want to talk to people. I didn’t want to go out home because I was afraid of meeting known people on the street.

I had a lot of avolition as well. Before memantine I would just handle avolition by doing a lot of effort. With memantine I feel like a normal guy.

But (there’s always a but) I still have some alogia. But memantine made my alogia a lot better, but I still feel I have some of it.

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Thank you for your post!

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Hi brugluiz, I’m glad that you feel better. Have you tried Sarcosine? Or any other supplements?
I read on the other thread that you are going to talk with your doctor about Galantamine, have you done that?

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Hi, @Marya!

I talked to my doctor about Galantamine and Memantine combination, but he was not convinced by the article I gave him. He thinks that maybe in the future we can test it as off-label (as we did with memantine), but not yet (I think he wants to see if memantine is being stable for me).

I haven’t tried any supplement yet. I want to try sarcosine, l-theanine and N-acetilcistein.

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