Do sleep disturbances contribute to cognitive impairments in schizophrenia spectrum and bipolar disorders?

everhopeful · October 7, 2019, 10:27am

ncbi.nlm.nih.gov

Do sleep disturbances contribute to cognitive impairments in schizophrenia spectrum and bipolar disorders?

JF Laskemoen, C Büchmann, EA Barrett, M Collier-Høegh, B Haatveit, TJ Vedal, T Ueland, I Melle, M Aas and C Simonsen, European archives of psychiatry and clinical neuroscience, Oct 2019 05

Sleep disturbances and cognitive impairments are both frequent across psychotic disorders, with debilitating effects on functioning and quality of life. This study aims to investigate if sleep disturbances are related to cognitive impairments in schizophrenia spectrum (SCZ) and bipolar disorders (BD), if this relationship varies between different sleep disturbances (insomnia, hypersomnia or delayed sleep phase (DSP)) and lastly, if this relationship differs between clinical groups and healthy controls (HC). We included 797 patients (SCZ = 457, BD = 340) from the Norwegian Centre for Mental Disorders Research (NORMENT) study in Norway. Sleep disturbances were based on items from the Inventory of Depressive Symptoms-Clinician rated scale (IDS-C). Their relationship with several cognitive domains was tested using separate ANCOVAs. A three-way between-groups ANOVA was conducted to test if the relationship with cognitive impairments varies between different sleep disturbances. These analyses revealed significantly poorer processing speed and inhibition in those with any sleep disturbance versus those without, also after adjusting for several covariates. The relationship between sleep disturbances and cognition was similar across SCZ and BD, and there were significant effects of insomnia and hypersomnia on both processing speed and inhibition. No association between sleep disturbances and cognition was found in HC. Sleep disturbances contribute to cognitive impairments in psychotic disorders. Processing speed and inhibition is poorer in patients with sleep disturbances. Impairments in these domains are related to insomnia and hypersomnia. These findings suggest that treating sleep disturbances is important to protect cognitive functioning, alongside cognitive remediation in psychotic disorders.

firemonkey · October 7, 2019, 10:38am

I’ve had problems getting to sleep from a young age. To quote my father:

Mima and I tended to be rather short of sleep. Because you would not go to bed early, had to have one of us stay with you until you went to sleep and tended to wake up with nightmares.

I’m not sure whether it’s related to any cognitive problems I have or not.

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Do sleep disturbances contribute to cognitive impairments in schizophrenia spectrum and bipolar disorders?

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