Did anyone use RASAGILINE?
Did anyone use RASAGILINE? Good for Brain and Negative symptoms and 5 times more powerful than Selegiline.
I used Flauxitine and the Gap between Flauxitine(Prozac) and RASAGILINE should be 5 weeks so I will start
taking RASAGILINE on September 15th and report it here with updates.
I read a study by Maryland researchers, 2 years ago, in which Rasagiline has improved avolition by 20%, but it was ineffective against other negative symptoms.
My main negative symptom is anhedonia. I would take Rasagiline but thereās no evidence that it can be helpful.
Good luck anyway, @anon93437440, keep us updated about it !!
Yes - I agree with this. Very little research on this medication in use for schizophrenia - only one study. But if you have easy access to it, and its inexpensive I guess it might be worth a tryā¦
Rasagiline Shows āModestā Effect on Avolition in Schizophrenia
Rasagiline has a modest effect in reducing negative symptoms in patients with schizophrenia, especially avolition, according to new findings published in Schizophrenia Bulletin.
Negative symptoms of schizophrenia are characterized by an absence of emotion and response, as opposed to positive symptoms such as hallucinations and delusions. They fall into four main categories, as Dr. Robert W. Buchanan of the University of Maryland School of Medicine in Baltimore, the studyās first author, explained in an interview with Reuters Health: poverty of speech; flat or blunted affect; anhedonia; and avolition, or lack of motivation.
Medications have had limited effectiveness in improving negative symptoms in schizophrenia, and these symptoms āare major determinants of poor outcome,ā Dr. Buchanan and his team write in their report, published online November 2.
Recent research suggests that impaired reward system function and disturbances in dopamine release may play a role in negative symptoms in schizophrenic patients, the researchers add.
Monoamine oxidase-B (MAO-B) inhibitors increase dopamine levels without the cardiovascular side effects of less-selective MAO inhibition, but studies of the MAO-B inhibitor selegiline for treating negative symptoms have had mixed results.
Dr. Buchanan and his colleagues decided to investigate the effects of a new MAO-B inhibitor, rasagiline, which unlike the older drug is not metabolized into potentially neurotoxic compounds. Both drugs are Food and Drug Administration-approved for treating Parkinsonās disease.
They randomly assigned 60 patients with schizophrenia or schizoaffective disorder and persistent negative symptoms to receive 1 mg of rasagiline per day or placebo for 12 weeks.
Full story here:
http://www.psychcongress.com/article/rasagiline-shows-modest-effect-avolition-schizophrenia-19939
Full Paper Here:
More details on the medication:
I am going to use Memantine starting tomorrow. Now, it is 11:36 PM so I will buy Memantine tomorrow and use RASAGILINE from September 15th. Iām replacing the Selegiline with it. In the past I used Selegiline 50 mg for a month and I was active all day long, as if I donāt have any negative symptoms but 50 mg can be toxic so I want to try Rasagiline as it doesnāt build tolerance inside the body and it is more bio-available and less dosage is required and is 5 times better than Selegiline but different mechanism of action. Selegiline 50 mg is very very good for depression and same canāt be said with Rasagiline as the research doesnāt say anything about it to relate to depression whatsoever. The good thing is it is very good for neuroprotective properties and very good for avolition too. Iāve Anhedonia+Avolition etc and treating avolition is good. Memantine will treat anhedonia.
Interesting. Where are you getting it from - a doctor is prescribing this to you (in India?) - is that right?
and
I always self medicate after researching ( searching on the internet ) about the drugs and health supplements I use, whenever I have enough money and then it turns out I do benefit from this but when I donāt have money then I struggle.
My Father is a Doctor. An Eye Specialist and my elder sister is also a Doctor, a Dentist and her husband is also a Dentist and her husbandās father is also a M.B.B.S Doctor. I also have my Fathers younger sisterās younger Son a Veterinary Doctor who did post graduation in USA and is working in North Carolina I think but I can only self medicate. Nobody knows Schizophrenia even though there are so many Doctors. Iām always on my own. I have no options left.
50 mg a single strip of 10 - 5mg tabelts. For Depression the highest dosage is 60 mg.
I read about many drugs on a Drug book published recently and it has more than 700 pages and is latest. I downloaded it from the internet for free. Piracy.
RASAGILINE should not be taken more than 1 mg per day and is very cheap when compared to Selegiline 50 mg. Today I went to buy Memantine as it is very good for Anhedonia. Rasagiline is good for Avolition. But itās Tueday today and this day every week the single shop that sells such medication in Vizianagaram Town is closed. I will get it tomorrow. Both Memeantine and Rasagiline are relatively cheaper and more effective. Memantine has no problems with drug interactions as there are 3 or 4 only but Rasagiline has many drug interactions so I will be careful.
Previously when I used Selegiline I followed the Selegiline diet. If I eat Tyramine foods it can lead to death but I didnāt read about drug interactions and not knowing drug interactions I quit selegiline and I decided to use Selegiline again but now that I know Rasagiline I prefer Rasagiline.
Olanzapine, Caffine ā¦etc have drug interactions with Selegiline which I previously took in large doses.
After using Fasoracetam+Coluracetam my Brain got upgraded and now Iām reading everything. I still canāt read, canāt read in a sense unable to focus or pay attention or continue reading but after the Brain upgrade Iām a better drug and health supplement user.
Sometimes I get thoughts that my original mother was raped and my current parents adopted me. Funny but real and scary and tormenting life. A loser life. Or almost loser. Celebration of being alive.
A few interesting threads discussing Memantine and other substances. If you have time to read 
Excellent for sensory overload/gating issues. I found a sweet spot that was a good anti-anhedonic compared to other things Iāve tried.
Memantine treatment reverses anhedonia, normalizes corticosterone levels and increases BDNF levels in the prefrontal cortex induced by chronic mild stress in rats.
from the website
Memantine, a non-competitive antagonist of NMDA receptors, has recently been used in Alzheimerās disease. The influences of memantine on behavioral changes, monoamine oxidase (MAO) activity and reuptake of both serotonin (5-HT) and dopamine in mice were examined in the present study. Memantine dose-dependently increased locomotor activity. This effect was inhibited by intraperitoneal (i.p.) administration of haloperidol. Furthermore, administration [intracerebroventricular (i.c.v.)] of memantine did not induce the head-twitch response (HTR). However, the 5-HT-induced HTR was potentiated byā¦ copyright issues
So Iāve decided to use Memantine and not to use any MAOI like Selegiline or Rasagiline.
OK, so you will not use Rasagiline anymore? Tell us how you feel on Memantine after a few weeks.
Good luck!
Today two hours ago I took 5 mg Memantine and slept for a while because I felt drowsy and sleepy and when I woke up I could actually play a game. Before that I couldnāt play the computer online game. I will take 5 mg Memantine twice ( morning and evening ) everyday. This is good and I can actually feel the results.
Currently Iām using
Alpha Lipoic Acid 600 mg daily
Abilify ( Aripiprazole ) 15 mg every night
Mementine 5 mg twice daily ( started today and gonna take the other 5 mg tonight )
L-theanine
Melatonin.
These 5 are what I take for my Schizophrenia treatment and will continue with these five.
I will try Rasagiline from September 15th 2016 ( 5 week gap between SSRI and MAOI ) as it is very very good and it is clearly written in the above article.
is it a antipsychotic or mood stablizerā¦!!! got curiousā¦???
Hey @far_cry0! How goes? Was wondering where you were.
@far_cry0!!! Where were you??