Depolarizing GABAA current in the prefrontal cortex is linked with cognitive impairment in a mouse model relevant for schizophrenia

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https://advances.sciencemag.org/content/7/14/eaba5032.abstract

Thus, we show that depolarizing GABAA currents in the ILC contributes to cognitive impairments in scPCP mice and suggest that bumetanide, an FDA-approved drug, has potential to treat or prevent CIAS and other components of the schizophrenia syndrome.

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I think I read that some people use very very low doses of this drug off label in autism for the same reason.

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