D-cycloserine an anti biotic for negative symptoms?
This is an anti biotic, bunch of info popped up but is it safe? anyone tried?
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This is old but may be still relevant.
BN van Berckel, CN Evenblij, BJ van Loon, MF Maas, MA van der Geld, HJ Wynne, JM van Ree and RS Kahn,
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology , Aug 1999
A hypofunction of the glutamatergic system and NMDA receptors in schizophrenia has been hypothesized. Therefore, stimulation of these receptors could be of benefit to patients with schizophrenia. D-cycloserine has been used for this purpose. This study reports the effects of 100 mg D-cycloserine, when added to typical antipsychotics in chronic schizophrenic patients exhibiting prominent negative symptoms, using a placebo-controlled, double-blind, parallel, design. D-cycloserine slightly worsened psychotic symptoms and general psychopathology as compared to placebo. D-cycloserine failed to change negative symptoms and had no effect on extrapyramidal symptoms. The exacerbation of schizophrenic symptoms may be explained by the antagonistic effects of this dose of D-cycloserine at the glycine recognition site of the NMDA receptor due to competition with the endogenous agonist glycine. Another explanation for the increase in psychopathology may be an interaction with the effects of antipsychotics on NMDA mediated neurotransmission. Thus, D-cycloserine in this study did not ameliorate schizophrenic symptoms. However, the fact that they actually worsened suggests that NMDA systems may be involved in the pathogenesis of schizophrenia. Further placebo-controlled studies with lower dosages of D-cycloserine, preferably in drug-free patients, are necessary to evaluate if D-cycloserine is of use for the treatment of patients with schizophrenia.
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I take an antibiotic for my skin, it does not make a difference. I could not see why it would anyway. Whats the science behind it? Sounds like something that is not worth trying.
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Minocycline cured my negative symptoms as long i was on it, but now it puts me into shock so im very scared i dunno what to do anymore
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