Several successful treatments used for cognitive deficit in schizophrenia exert their action by enhancing neuroplasticity. This suggests that the combination of those pharmacological treatments with non-pharmacological therapies such as cognitive training could represent an advancement in the treatment of cognitive deficit in schizophrenic patients.
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Is there any meds in clinical trials for cognitive symptoms? I know there are some for negative symptoms.
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RL-007, I believe. Safety, Biomarker Study of RL-007 in Subjects With Schizophrenia - Full Text View - ClinicalTrials.gov
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Also KarXT, BIIB-104, BI-425809, PF-03463275, and ASP-4345
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It is assumed that, the main objective of this research is to prove that the existence of a relationship (association) between the factors A,B and C and those symptoms of sz that be called cognitive deficit ,in order to design pharmaceutical drugs capable of correcting the chemical crisis factors to getting rid of such a symptoms
But as we see,the association is based on a merely prior point of view that relied on the presence of synchronization between the diagnosis of deficiency symptoms and the presence of changes in the ratios of those factors,
Hence,the theoretical notion that simply thinks that ; this come from that ,without any scientific procedure to verify the credibility of such a point of view
As we say,any aspect of the imbalance in the level of the brain substances or its functions ;
1-is just a chemical Reactions
2- It did not occur according to the directives of an autogenous genetic messages program or/ in agreement with a psychic will or/due to the influence of external sensory environmental stimuli or/anatomical defects or/ pathological deficiencies or any Disease
3- Any aspect of the chemical change (whatever it is ) in a citizen with sz,occurs only during the period time of waking and disappears completely during the period of deep sleep !
4-The chemical reactions / or the functional changes, is arise as a Result of the influence /interference or interception of the Casual Factor (H) with the final outcome of the understood signals that exist from all neuronal receptor cells throughout each single mental process
5- The casual factor (the maker of pathological psychosis) does not effect on the sensory inputs or the transmission signals which broadcasting from the self- thought’s source
So that,the chronic problem with all researches conducted on the sz,is the existence of an eternal deficiency in finding realistic casual relationships between all objective pathological factors (genetic,chemical …etc) and a causation of the sz’s symptoms emergence (at least)
Symptoms per se,the reason of its occurrence,the logic of its understanding,explanation is incomprehensible according to the background of the objective pathological factors characteristics ,or even the content of the theory’s data it adopts
You should know the fact that,description the symptom ,as seen by the pure mind ,is the straight line that form the shortest distance between the diagnosed symptom and its actual reality
So,when you deliberately (for some reason) describe the symptom with what is not in it, or you deny part of the symptom (that you don’t like it),or even ignore everything in the actual symptom,You will not find a medical treatment that treats the actual symptom,and the citizen’s complaints will abound about the continuing impact of the malicious symptom on his thoughts,feelings,behavioral trends and the ways to enjoy the life’s pleasures !
The cognitive deficit symptom is not known or understood as it was in its actual reality
Although there is actual objective information (before the sz and during) about oneself ,others and the world of things fixed in the citizen’s memory,but by action of sz, his objective knowledge turns into delusional knowledge based on his own objective self-knowledge data
The real concept’s data about the real world that he knew (before the sz) was exchanged during the activation of sz into unreal mental concepts ,this is occurs only by action of the vocal ,imaginary and emotional emitter (H) in most time of waking ,attention and self-aware !
This is the summary of the symptom be called “cognitive deficit” in the actual reality
The questions;
What are the mechanisms used by the vocal emitter (the thing be called hallucination) to transform the citizen’s objective knowledge data into fictitious knowledge that distances the citizen’s mind from the actual reality that all people aware of (even if they differ in understanding or explanation this reality) ?
What is the chemical intervention that inhibits the course of the alterations that occur in the data content of the self-knowledge of the citizen that related oneself,relationships with others and the world of things ?