Results: Clozapine showed a much lower D2 occupancy (16%-68%) than risperidone (63%-89%) and olanzapine (43%-89%). Risperidone and olanzapine gave equal D2 occupancies at doses of 5 and 20 mg/day, respectively. All three drugs showed greater 5-HT2 than D2 occupancy at all doses, although the difference was greatest for clozapine.
Conclusions: Clozapine, at doses known to be effective in routine clinical settings, showed a D2 occupancy clearly lower than that of typical antipsychotics, while risperidone and olanzapine at their usual clinical doses gave the same level of D2 occupancy as low-dose typical antipsychotics
Does this mean that you are considering Clozapine again?
I think there are other factors at play with clozapine. Like they find the level of pregnenolone in patients on clozapine to be higher than patients on other meds. I think clozapine indirectly influences nmda receptors or something. (which is why sarcosine is found unnecessary while on clozapine).
You are reading my mind! Honestly I think about it everytime I feel bad bcz of staying in bed but my original pdoc said it won’t help, also scared of its side effects, 5 black box warnings. I also read its hard to come off, much harder than other APs.
Clozapine may cause serious and potentially fatal adverse effects. Clozapine carries five black box warnings, including (1) severe neutropenia (low levels of neutrophils), (2) orthostatic hypotension (low blood pressure upon changing positions), including slow heart rate and fainting, (3) seizures, (4) myocarditis (inflammation of the heart), and (5) risk of death when used in elderly people with dementia-related psychosis
Some users here had incontinence on it, bed wetting.
It also works more on Serotonin than Dopamine vs other APs, it also works on Gaba and Histamine.
I should ask my pdoc if he ever had a patient like me with such severe negative symptoms lol
yea i wet my bed once in a while… but now i make sure i go pee right before bed and that helps… i have a hard time holding it since taking clozapine so i have to make sure i go regularly.
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