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Even before the onset of schizophrenia, irregularities in key brain areas are already present in individuals at higher risk of developing psychosis, a Yale-led study shows.
The findings identify a potential marker for the debilitating disease that afflicts 1% of the world’s population and suggest at least a partial explanation for why schizophrenia most typically manifests itself in young adulthood.
The new study, published online Aug. 12 in the journal JAMA Psychiatry, builds on work at Yale that shows schizophrenia is associated with marked alterations in connections between the thalamus, a major relay system in the brain, and the frontal cortex, which is involved in higher-level cognitive functions.
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