Its good news i was following PF-04958242 for a few years till it Pfizer stopped research on it, Im glad someone now has a chance to bring it to market. Since it targets the AMPA receptor it could also be a antidepressant.
Yeah, I was concerned when Pfizer gave up their neuroscience research, glad someone is pursuing it.
"Comparing the two groups, the researchers reported, “PF-04958242 significantly reduced ketamine-induced impairments in immediate recall and the 2-Back and spatial working memory tasks (Cogstate Battery), without significantly attenuating ketamine-induced psychotomimetic effects. Interestingly, PF-04958242 completely reduced the ketamine-induced impairments in spatial working memory.”
This research suggests that AMPAR potentiators may have a role in the treatment of the cognitive symptoms associated with schizophrenia, and the strong congruity between the animal studies, human studies, and in silico modeling are exciting results for early translational research."
Yeah, Tbh this is the drug im most excited about, my positives are now stabilized just need something to improve cog and neg maybe then ill feel semi normal again. I find it interesting that its a glycine reuptake inhibitor too.
Wouldnt it be amazing if it completely restored cog to us all, I mean i had to learn how to shower again after my first break I became very stupid compared to my former self. What about you twinkle are you looking forward to this one?
It would be great if they can figure out something, it would be the beginning of many new potential treatments.