Antipsychotics for acute treatment of first episode schizophrenia

No significant difference to treat positive symptoms of psychosis were found between treatments, and with the exclusion of open label studies – olanzapine showed superiority over haloperidol and quetiapine. Changes in doses of haloperidol or risperidone did not impact on the overall efficacy of treatment
Olanzapine was significantly superior to haloperidol and risperidone in treating negative symptoms.