Anti inflammatory medications and supplements in schizophrenia


The examined anti-inflammatory agents included aspirin, celecoxib, omega-3 fatty acids, estrogen, selective estrogen receptor modulator, pregnenolone, N-acetylcysteine, minocycline, davunetide and erythropoietin.

Results: Sixty-two double-blind randomized clinical trials studying 2914 patients with schizophrenia met the inclusion criteria for quantitative analysis. Significant overall effects were found for anti-inflammatory agents for reducing total, positive and negative symptom scores in the Positive and Negative Syndrome Scale. Cognitive improvements were significant with minocycline and pregnenolone augmentation therapy. General functioning was significantly enhanced by overall anti-inflammatory agents. There were no significant differences in side effects compared with placebo.


I had to be on minocycline for other reasons. It was absolute hell for the month I was on it. I have a weak suspicion that it interacts badly with abilify.

Also I tried NAC and it seemed to definetely interact badly with abilify. I was becoming suicidal and had to stop taking NAC after only a few weeks.


Anti-inflammatories, eh? :thinking:


I think melatonin is anti inflammatory as well, although it wasn’t included in this study. Melatonin has a very short half life.