Anti - Inflammatories may cut Negative Symptoms of Schizophrenia

[Wave]

VIENNA, Austria — Off-target actions of currently approved drugs have shown benefit on some symptoms of schizophrenia, a new research suggests.

Specifically, ondansetron and simvastatin showed modest effects in reducing negative symptoms and a trend toward a benefit on cognition in established disease.

Simvastatin is an HMG-CoA reductase inhibitor with anti-inflammatory properties, and ondansetron is a 5-HT3 (5-hydroxytryptamine = serotonin) receptor antagonist. Statins decrease levels of C-reactive protein, and 5-HT3 antagonists decrease the tumor necrosis factor-α response to immune activation in monocytes.

http://www.medscape.com/viewarticle/842995

[darksith]

krill oil ( omega 3 ) has helped. …it is a natural anti_inflammatory.
take care

[Dude1]

I was on simvastatin and I seemed to feel a little better on it.

Then I started getting slightly high fasting and non fasting blood sugar, and tight muscles so I stopped.

I just had a physical finally and my blood results showed very high cholestoral and tryglicerides and my A1c showed begining high.

I am just starting metformin, lipitor, and fenofibrate(for high triglicerides)

So far I am doing good I was scared becuase side effects from these but It will be my second day tomorrow.

So far so good with side effects.

[anon47866227]

amisulpride has really helped me