I think this study has already been mentioned in the forum here.
And well, a negative result is still good, it helps direct efforts to more fruitful endeavours.
If a patient does not respond to clozapine, which is the most powerful drug available, there’s a high chance that he will not respond to a mild experimental add-on. But it was worth a try.
At least the side effect profile did not differ from the placebo group, indicating that taking large doses of NAC might be safe.
There’s hope that a combination of NAC and glycine might work stronger, I posted a link to a recent study in the forum yesterday. Unfortunately, that study was tiny, but it’s still interesting.
# GlyNAC supplementation reverses aging hallmarks in aging humans (18 August 2022, news report)
Supplementing Glycine and N-Acetylcysteine (GlyNAC) in Older Adults Improves Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Physical Function, and Aging Hallmarks: A Randomized Clinical Trial (Kumar et al., 2022), in Journal of Gerontology