A list of medications or supplements under study

Medications
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This is not an all-inclusive list, there are other medications that are being investigated but aren’t recruiting study participants right now.

This is just a partial list from clinicaltrials.gov that are recruiting or will be in the future.

Many are already approved drugs being considered for a new use (sz).

When the info was readily available, I put what symptoms the treatment was for.

DMXB-A
Levetiracetam
URB597
SEP-363856
sulforaphane
Tryptophan (MRI investigation in sz and healthy controls)
L-Carnosine
ASP6981
Memantine (negative and cognitive)
MK-8189 (acute sz)
DSP-5423P
Tiagabine
L-tetrahydropalmatine
sodium nitroprusside
NaBen
Pimavanserin
AUT00206 (positive, negative and cognitive)
BI409306 (prevention of worsening in prodromal psychosis and early illness)
Tocilizumab
LY500307 (negative symptoms and cognitive impairment)
Siltuximab
Vortioxetine (negative symptoms)
isradipine (cognitive impairment)
Basmisanil (cognitive impairment)
Curcumin
Minocycline (negative and cognitive)
Vestibular stimulation
Microbiome studies
Visual remediation (eye training)
Raloxifene
Theta burst stimulation
Dextroamphetamine (cognitive)
Exenatide
AVL-3288
TAK-041 (motivational anhedonia)
Ondansetron
Glyceryl Trinitrate (cognition)
Lu AF35700 (treatment refractory sz)
N-acetylcysteine (cognitive and negative)
Simvastatin
Sodium Butyrate (cognitive impairment)
Vorinostat added to clozapine
berberine (metabolic syndrome in sz)
Oxytocin (social cognition)
Cannabidiol
Prebiotics (cognition and weight gain)
PF-03463275 (cognitive impairment)
Plasma Exchange
Intravenous immunoglobulin
D-Cycloserine with CBT (delusions)
Prednisolone in early psychosis
DAR 0-100A (working memory in schizotypal personality disorder)
Losartan
Omega 3
Minocycline combined with omega 3 for at risk mental states
Gapapentin for patients at high risk for psychosis

Also many tDCS, rTMS, biomarker studies for diagnosis, treatment response, etc.

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Good list, thanks for taking your time to do this.

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Thanks for ur good effort…!!! I mainly like med for negative symptoms…

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What are u upto sis … @twinklestars …have a good night…

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Just going to bed. You just waking up on the other side of the world?

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Yes sis its going to be 1.00pm soon …!!! I am just basking sunlight on top of my house…

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I remember when i did my own little reseach when i was young i read about oxydocine. If i remember correctly its a hormone that makes anymals not to leave their cubs. Kind of like a motherly love hormone. I dont know so much about sz and how could oxitocine help with sz.

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Oxytocin.

People have it too, it is produced during times of bonding, such as sex, childbirth, nursing.

They are testing it on social cognition/social withdrawal in sz.

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i remember the drugs for diseases like bird flu (deadly) for the military paid well. i did not want to expose my family to those though.

such enormous amounts are nicured in new drug developments, (millions),
who gets all that money?

i’d need to be paid ‘highly’ to test their meds for them.

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Notably missing, because they are not currently recruiting for studies

RP5063
F17464
Evenamide
MIN-101
Xanomeline with tropsium chloride
Vanderbilt’s muscarinic drug
And lumateperone (ITI007)

Plus at least a few others in early stages.

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This is a post i am looking for… thanks for sharing…!!!

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This is absolutely AWESOME :trophy::trophy::trophy::heart_eyes:

Seriously this is awesome - Thanks a lot.
Do you have a curated version :wink: like a TL;DR version …

Just joking …this is so awesome - thanks again …a lot of research to do…
What are your favs you are waiting for?

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Mine are aut00206 and min 101…

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Thanks for the list twinklestars!

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I think that the first priority is to make the medications safe.
As safe as possible.

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I am really curious about the results of the unusual stuff, like plasma exchange and theta burst stimulation.

Also always nice to know about low risk dietary supplements like curcumin, prebiotics and sulphorophane (broccoli sprout extract).

Other than that, the usuals - ITI 007, RP5063, Evenamide, MIN-101, etc.

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Are they part of stem cell…!!! See ya tomorrow …have a good sleep…!!!

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No, I don’t know what the theory behind plasma exchange or theta burst stimulation is.

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Sounds interesting… we will have to wait …!!! Take care…

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Where can i read more in details about it…?? Any links…