Treatment of early non-response in patients with schizophrenia: assessing the efficacy of antipsychotic dose escalation

News
1

DISCUSSION:

Since a lack of early improvement predicts poor response to short-term antipsychotic treatment in patients with schizophrenia, several treatment strategies have been proposed to enhance treatment outcome in early non-responders. A novel clinical trial design involving a placebo arm and re-randomization of early non-responders to increased or maintained antipsychotic dose was developed. The study design described in this report provides a robust method to assess the value of antipsychotic dose escalation in patients with schizophrenia who demonstrate poor initial treatment response.

Source:

1 Like
2

Why keep meticating non responders?

3

In the study they say:

the “novel trial design was developed to assess the potential utility of antipsychotic dose escalation in patients with an inadequate initial treatment response.”

So - raising the dose level can be a useful strategies for people who initially take a low dose and don’t respond.

1 Like