Conclusion:
Given this favorable preclinical profile BMS-933043 was selected for further development to support clinical evaluation in humans.
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Additional information on this new medication in development:
It seems that the medication had some type of problem in testing and the company has discontinued development of it:
http://adisinsight.springer.com/drugs/800036214
Background Information:
Full research paper:
The Novel, Nicotinic Alpha7 Receptor Partial Agonist, BMS-933043, Improves Cognition and Sensory Processing in Preclinical Models of Schizophrenia
Clinical Trial info: Multiple Ascending-Dose Study to Evaluate the Safety, Tolerability and Pharmacokinetics of BMS-933043 in Healthy Subjects
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I dont even want to hear about this… After a while it just gets so frustrating…none of these cognitive drugs are coming out anytime soon everythings in phase 1-2 clinical trials meaning well have to wait for the greater part of a decade for any of these drugs to come out. And then theres the possibility they will fail in the trials. All in all it seems like the drug companies have either forgot about schizophrenia or simply dont care…
Yes a lot of them are in phases 1-2. Yes they they take a long time to come out ,presuming they pass through the clinical hoops, but surely the fact that drugs are being trialled is proof enough that schizophrenia has not been forgotten.
Re the lengthiness of the process there may be reasons for that. http://www.ca-biomed.org/pdf/media-kit/fact-sheets/CBRADrugDevelop.pdf
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It is good to see there’s still work being done on these aspects of the illness. I heard a lecture of one of my countries top psychiatrists that was pretty sobering on this matter. He told that, after the decade of the brain ('90-'00) when neuroscientific advances were thought to solve and cure mental disorders within a few years, nowadays disappointment about its actual progress reigns among professionals. Yes, ever more genes are correlated, some possible biomarkers have been identified, but as things stand, the mechanisms that transform anomalies of such kinds into the anomalous experience we are suffering from are far from known, and hopes and promises have been adjusted accordingly. One could say that is all a matter of time. Though in this lecture, it was also said drug companies now have been allocating their funds to illnesses that are far better understood, because it has more likely return on investment, given the disappointing progress in neuroscientific approaches of mental illness.
Sadly, there is a bit of feedback loop there: more research money, more advances, more ROI, more research money - or so it seems to me.
It is well known to historians of psychiatry that it oscillates between biomedical approaches and psycho-social approaches. Following the disappointing advances of the neurosciences, we might see a swing towards the latter now.
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You don’t seem to suffer from significant cognitive impairment I can tell from the way you write that you stand out intellectually.
You’re lucky, 85% of schizophrenia sufferers have some form of cognitive impairment.
I know I suffer from it, but unfortunately it seems like all of the cognitive enhancers are in early phase trials. None of them will be out before 2020, so I have to wait and struggle in the meantime.
Imagine after the release of the first cognitive drug everyone on the forum starts writing with the same academic voice as you do.
Its not too far fetched that that could happen.
Whilst my cognitive difficulties may not be as severe as someone with schizophrenia you would be mistaken in thinking I have none.
Areas of cognitive difficulty for me include (1) slow processing speed (2) Executive functioning(NB organising and planning). I did a brain test publicised by sz admin back in 2007(no longer available) and scored between 1.5 and 2 standard deviations below average for executive functioning (3) Whilst my verbal intelligence is in the very superior range my spatial intelligence is borderline/low average. My verbal intelligence is significantly higher than my nonverbal intelligence.
Although never diagnosed as such(I come from a generation where learning problems and above average intelligence weren’t seen as co -existing in the way they are now) I have all the signs of a learning difficulty. Terms used for people with above average/high intelligence and areas of cognitive difficulty include “twice exceptional " and " gifted but learning disabled”.
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