The More Severe the Schizophrenia, The Bigger the Benefit from Medications

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This is the kind of science that is important for people to learn about:

Initial Severity of Schizophrenia and Efficacy of Antipsychotics

Results:

for both types of patients, the interactions between baseline symptom severity and treatment were statistically significant (P < .01). The greater the baseline severity was, the greater the magnitude of the differences was between active treatment and placebo.

But also need to be aware of this:

We can expect benefits of antipsychotic drugs for the full spectrum of patients likely to be treated for acute schizophrenia and for highly symptomatic patients with predominantly negative symptoms. Toward the mildest end of the spectrum, clinicians need to be aware that patients benefit less in terms of symptom improvement but may experience full adverse effects of antipsychotics.

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Interesting but rather much what Iā€™d expect if the medication is superior to placebo. Similar drug response-placebo difference has been found for increasing severity of depression.