Study links genes with function across the human brain

Study links genes with function across the human brain

Many psychiatric disorders have genetic causes, but the exact mechanism of how genes influence higher brain function remains a mystery. A new study provides a map linking the genetic signature of functions across the human brain, a tool that may provide new targets for future treatments.

Led by Bratislav Misic, a researcher at The Neuro (Montreal Neurological Institute-Hospital) of McGill University, a group of scientists performed machine learning analysis of two Open Science datasets: the gene expression atlas from the Allen Human Brain Atlas and the functional association map from Neurosynth. This allowed them to find associations between gene expression patterns and functional brain tasks such as memory, attention, and mood.

Interestingly, the team found a clear genetic signal that separated cognitive processes, like attention, from more affective processes, like fear. This separation can be traced to gene expression in specific cell types and molecular pathways, offering key insights for future research into psychiatric disorders. Cognition, for example, was linked more to the gene signatures of inhibitory or excitatory neurons. Affective processes, however, were linked to support cells such as microglia and astrocytes, supporting a theory that inflammation of these cells is a risk factor in mental illness. The genetic signature related to affect was centred on a brain region called the anterior cingulate cortex, which has been shown to be vulnerable in mental illness.

Published in the journal Nature Human Behaviour on March 25, 2021, this study draws a direct link between gene expression and higher brain function, by mapping gene signatures to functional processes across the human brain.

“In this work we found molecular signatures of different psychological processes,” says Misic. “This is exciting because it provides a first step to understand how human thoughts and emotions arise from specific genes, biological pathways and cell types.”


According to the data of personal feeling , perception and the bilateral coexistence with the health condition be called SZ,it is seems as a New Whole Living Parasitical Psychological Self be add suddenly to the internal basic nature of the person,it have independent existence,knowledge,behavioral directions contrary to the person oneself and the general reality,and above of all it is not human in nature from A to Z

Therefore the Sz condition as it as in its nature is considering from the category of the higher parasitical condition (not hereditary disease from all aspects of views )

Even if the functions of the human genome are finally responsible for creation of the human psychological self,functional mind,thoughts,imaginations,memory,feeling, sensual perceptions,understanding and all forms of human behaviors, that is irrelevant the creation of sz condition itself at all BECAUSE it is driven by a parasitical pathogen (adapted in its structure /function to work on the human psychological self and its attachments) which is not a functional product of the human genome !

This means that,the Sz pathogen is a psychic parasite in nature,have not an organic body/cellular structure ,chemical composition or specific metabolism ,just it send a messages of orders /directions (operating orders) look like the messages of the human gene which creating a spoken mentally concepts in the conscious mind of the human host !!

We belief that,the first early main task of science is to define a clear/ accurate definition for the essential nature of the sz health condition itself independently about the human psychological health condition or the biological ,a basic condition that the definition is matches the actual reality of the sz as it as And as everyone with sz coexists with it inside himself though his conscious mind and the feelings of emotion

That is in order for there to be a specific / focused research on the cause of the sz condition (the creation cause /functional cause)

In the case,if the basic condition is ignored,the research becomes a luxury in waste time /effort in just writing the articles !

Please,do not put any definition for the sz condition,while the person who suffers from sz and coexists with its effects dost not realize any match between the theoretical definition and the living condition that he perceives inside himself

I’ve heard of this before that neuroinflammation may cause symptoms of mental illness. I take Abilfy and believe it has neuro -protective benefits. I say this because my judgment and my memory have improved while on it. I can’t say I’m back to the way I was before I became ill but after suffering several bouts of psychosis, I’m happy to say that my brain is functioning better than it did while psychotic. I have taken Abilify for three years continually now. My brain’s function has improved slowly but surely. I work now as a teacher online. It has helped that my brain is functioning much better. But, I still have to focus really hard to remember things that I did not pay attention to memorizing. But, I attribute this to my age more than my illness. I think that it is important to take my medication because it does help with my cognitive abilities. I can attest that the reason I’m able to work/teach is because my brain is functioning better than it used to. I teach healthcare professionals who are not easy to please and are serious about their learning. I know if I am incoherent or discombobulated in some way, they will pick up on this and complain about me. But, so far, all is well!!

Although it is impossible to diagnosing a disease of any kind embodied in the psychological /biological nature of the person,the impossible of diagnosing a cause (any cause),the impossible of discovering the mechanisms responsible for inducing the change,disorder that leads to the emergence of the symptoms that be felt internally by the person or even the symptoms that be diagnosed by the Dr.,

BUT,there is no objection to using one /all treatment methods that be known to science to reduce the harm that these symptoms cause to the degree that the person is able to practice his behavioral habits to an acceptable extent that meet the requirements of his personal life and make him feel reassured and satisfied