Patients with schizophrenia appear to be at a lower risk of hospitalization for physical health issues when taking high doses of two or more antipsychotic medications concurrently (polypharmacy) than when taking just one antipsychotic medication (monotherapy) at the same equivalent dose, according to a study published in March in AJP in Advance. “When patients were treated with high-dose antipsychotic monotherapy, … they had approximately a 20% higher risk of severe cardiovascular outcomes leading to hospitalization compared with periods when the same patients were treated with corresponding high-dose combination therapy,” wrote Heidi Taipale, Ph.D., an assistant professor at the Karolinska Institutet, and colleagues
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