Seems like we’re getting close to understanding what causes schizophrenia

[TheLogician]

There have been several articles released over the last few weeks indicating we might really be honing in on what causes this mess. The twin study, the orginoid study and Korean paper that just came out. Feels like we’re almost there. What do you guys think?

[anon8411913]

Can you share with me those articles??
I am very interested

[TheLogician]

Sure thing. I’ll link the posts from on here. There summarized so you won’t have to read 100,00 words lol.

Integrative metabolomics-genomics analysis identifies key networks in a stem cell-based model of schizophrenia

# Integrative metabolomics-genomics analysis identifies key networks in a stem cell-based model of schizophrenia Schizophrenia (SCZ) is a neuropsychiatric disorder, caused by a combination of genetic and environmental factors. The etiology behind the disorder remains elusive although it is hypothesized to be associated with the aberrant response to neurotransmitters, such as dopamine and glutamate. Therefore, investigating the link between dysregulated metabolites and distorted neurodevelopment holds promise to offer valuable insights into the underlying mechanism of this complex disorder. In this study, we aimed to explore a presumed correlation between the transcriptome and the metabolom…

Monozygotic twins discordant for schizophrenia differ in maturation and synaptic transmission

https://www.nature.com/articles/s41380-024-02561-1 Study Focus: Examines monozygotic twins discordant for schizophrenia to understand neurophysiological differences1. Schizophrenia Prevalence: Affects approximately 1% of the global population, with genetics, epigenetics, and environmental factors playing roles1. Twin Study: Fibroblasts from two pairs of twins discordant for schizophrenia and three pairs of healthy twins were used to create iPSC models1. Neurophysiological Findings: Neurons from schizophrenia patients showed less arborization, hypoexcitability, immature spike features, and reduced synaptic activity1. Gene Dysregulation: Significant dysregulation in synapse-related genes was…

New study into identical twins suggests a possible treatment for people with

The article discusses a new study that suggests a potential treatment for schizophrenia. It involves research on identical twins, which has led to insights that could inform therapeutic approaches for the disorder. The study seems to be significant in the field of mental health and offers hope for those affected by schizophrenia.

"We identified 4 proteins and 19 genes that are causally associated with schizophrenia"

(via David Slattery on Twitter) New in Molecular Psychiatry: Genetic regulation of human brain proteome reveals proteins implicated in psychiatric disorders “we identified 4 proteins and 19 genes that are causally associated with schizophrenia” # Genetic regulation of human brain proteome reveals proteins implicated in psychiatric disorders - published 9 May 2024, by Jie Luo et al.

Key brain activity linked to schizophrenia onset, says a Korean study

The team stressed that this correlation suggests that patients with higher reactive astrocyte activation in this region experience more severe positive symptoms, linking astrocyte activity to the intensity of hallucinations and delusions.

[TheLogician]

If you click the links it gives you a better summary.

[anon8411913]

I read that a bit. Thanks @TheLogician

I also want to add. My pdoc is one of the best doctors in my country, and she said that psychiatry is progressing A LOT last decade. She said they have more and more answers.

So it could mean we are truly closer to the answer!!

[TheLogician]

Here’s hoping check this out. At least one of those papers is based on this guys work. I think you’ll enjoy it.

How We're Reverse Engineering the Human Brain in the Lab | Sergiu P. Pasca | TED

[shutterbug]

Emissions from improperly tuned toasters. Try and toast a bagel in a unit that’s off-frequency and next thing you know half the neighbourhood has SZ.

You’re welcome.

[TheLogician]

Just ask @rogueone. It’s always been toasts.

[SkinnyMe]

Wonderful! 15151515

[magz]

I hope that lead to better treatment after we know 100% the cause(s).

[san_pedro]

in my case, i know what ‘‘caused’’ it

[TheLogician]

I feel like I have a pretty good handle on the series of events that led to me developing it, but in terms of the neurology, I, like everyone else, am completely in the dark.