Scientists at Harvard University and the Broad Institute examined the genomes of 64,785 people around the world and found that those who were with the debilitating psychiatric disorders more likely to have mutations in a common gene, according to published this Wednesday findings. People with schizophrenia – more than 21 million worldwide – generally have less gray matter and fewer connections in their brains than healthy peers. But scientists are not sure why. The research, which for the first time, suggests that changes in a gene called complement component 4 or C4, in short, could be important. The gene was previously known to help the immune system to target infections. The study shows the possible reasons is that the symptoms of schizophrenia of not less than 3.5 million Americans trigger of 1% of the population. Schizophrenia symptoms such as hallucinations, cognitive difficulties, hallucinations and abnormal social behavior changed. However, psychiatrists have been mystified about its origins and biological bases. “The basic scientific dilemma in schizophrenia and in all mental illness is that we do not even the most basic things about how these diseases start known,” said Dr. Steve McCarroll, a geneticist at Harvard University and one of the authors of the study.'
Could be the reason sz’s have fewer neural connections is that they are more likely to be isolated due to their disease. I recall in a class at school seeing maps of the neural connections of mice who had been socialized and mice who were kept in isolation. The brains of the socialized mice had many more connections.
The article is littered with a pattern of syntax errors characterised by the abrupt cessation of intelligible flow followed by the birth of a new and often unrelated sentence. This phenomena has rendered the grammatical correctness significantly compromised as well.
I learnt more by reading a Synaptic Pruning Wiki, but at least the article gave me that notion
There are also many studies that support your observation, but explore extroversion vs introversion instead. Introverts who actively push themselves into extroverted roles (particularly in relation to social contexts) have a statistically significant increase in likelihood to be less neurotic and more emotionally stable.
Synaptic pruning could very well be accelerated by negative social experiences such as the inherent isolation observed in introverts with mental illness. Though, I expect there are numerous other concurrent factors, many of which may have higher percentages of contribution to the manifestation of SZ gene expression in later life. Stress being what I’d put my money on. Environmental (pollution, radiation, noise levels, elevation, geographical orientation [seasonal factors/ozone etc] etc.], emotional (self explanatory?), physical (injuries/traumas to the body, surgery, smoking, drug abuse etc.).
