This is interesting - but “animal models” of schizophrenia (where they try to create what looks like “schizophrenia” in an animal, and then cure the animal) are famously imprecise as nobody knows what exactly schizophrenia is either in humans or animals).
Now, researchers at the University of Geneva (UNIGE) have taken a decisive step in understanding this disease. They have deciphered a cellular mechanism leading to the desynchronization of neural networks, and corrected this organizational defect in an adult animal model, thereby suppressing abnormal behaviours associated with schizophrenia. The results, published in Nature Neuroscience , show that a therapeutic intervention is possible at all ages.
Full Story:
Full Free Access to Original Research Paper from Sci-Hub:
cure maybe, at lest is sounds that way, hiper neurons , the gifted part to schizophrenia may made smarter people recess back and relearn books math etc. skills may have to be relearned too. id like to jump on it just to know it works in research testing. we may be on the brake of re mapping new frontier’s in brain behaver. and capabilities and beyond.
PV interneurons again. That was the same type Dr. Lodge used in his neuronal transplantation animal studies.
Edit: so the paper is pay to access, but from what I could see for free, looks like a chemical or drug. “Rescuing parvalbumin interneuron excitability with pharmacological or chemogenetic approaches was sufficient to restore wild-type-like CA1 network dynamics and hippocampal-dependent behavior during adulthood.”
Hahahaha that’s awesome!!!
Awesome news for schizophrenics !!!
Remember, Albert Einstein made his main scientific breakthroughs in Switzerland!!!
I also saw that the level of mathematics studies at the University of Zurich is high.
Thank you @SzAdmin
There is at least 1 drug targeting PV interneurons in early human trials.
“In behavioral tests, AUT00206 rescued behavioral deficits in cognitive function in the absence or presence of antipsychotic treatment. Chronic dosing reversed the reduced PV cell density, consistent with an enhancement of PV-interneuron function. These results suggest a targeted means to rescue PV-interneuron function which may provide a novel approach to the treatment of schizophrenia.”
I’m wondering if this might mean it could be possible, in the future, to have a drug that you could be on for a period of time, and then not need anymore.
