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Polygala tenuifolia (supplement)

lately ive been looking at supplements for various thing and i found out about this through an ad so looked it up, has anyone tried it or know about it? here are some studies and articles i found:

https://www.ncbi.nlm.nih.gov/m/pubmed/29056891/

https://www.tandfonline.com/doi/full/10.1080/19768354.2014.982176

https://selfhacked.com/blog/polygala-tenuifolia/ from this:

  1. Polygala tenuifolia Improves Memory

In a study (DB-RCT) with 48 healthy people, polygala improved spatial and verbal memory. Those who received it also made fewer errors and scored better on the test measuring working memory [7].

Polygala extract improved both spatial and non-spatial memory in aged mice [8].

It also improved short-term memory in rats with drug-induced memory impairment [9].

This supplement improves memory by:

• Inhibiting the enzyme acetylcholinesterase (AChE). This reduces the breakdown of acetylcholine [10].

• Inhibiting MAO enzymes. This reduces the breakdown of dopamine, serotonin, and norepinephrine [8].

• Increasing BDNF in the brain (hippocampus) [11].

• Promoting the growth of new neurons in the hippocampus (important for the creation of new memories) [12].

  1. Polygala tenuifolia May Improve Cognitive Function in the Elderly

In a study (DB-RCT) with 53 elderly subjects, polygala extract enhanced cognitive function [13].

Polygala extract also reversed cognitive impairments in rat models of Alzheimer’s disease, and mice models of stroke [10, 14].

  1. Polygala tenuifolia May Combat Depression

Polygala and its derivatives have antidepressant effects in rats and mice [15, 16, 17, 18, 19].

In mice, a saponin from polygala was more effective than a drug used to treat depression (duloxetine) [18].

Animal studies show that polygala combats depression by:

• Blocking MAO enzymes. This increases dopamine and serotonin levels [15, 18]

• Increasing antioxidant enzymes (SOD) [15]

• Decreasing cortisol and the stress response (HPA axis) [15, 16]

  1. Polygala tenuifolia May Reduce Anxiety

Mice treated with saponins derived from polygala showed signs of reduced anxiety [20].

  1. Polygala tenuifolia Is Anti-Inflammatory

Polygala and its derivatives reduced the production of inflammatory cytokines TNF-alpha, IL-1beta, and the master-regulator of inflammation NF-κB in white blood cells (macrophages) [21, 2].

Polygala also reduces the production of nitric oxide (NO) and iNOS, thereby reducing inflammation [21]

  1. Polygala tenuifolia May Improve Sleep

Tenuifolin, derived from polygala, has sleep-enhancing effects in mice. It prolongs both REM and NREM sleep [22].

Polygala saponins also had sedative effects and prolonged sleep in mice [20].

  1. Polygala tenuifolia May Be Antipsychotic

Polygala saponins reduced drug-induced hyperactivity in mice and rats. They may act by blocking serotonin and dopamine receptors [23].

In addition, polygala extract reduces cocaine-induced psychotic behavior in mice [24].

  1. Polygala tenuifolia May Help with Dermatitis

Its extract reduces stress-induced dermatitis in mice [25].

  1. Polygala tenuifolia May Help Combat Cancer

Polygala compounds killed human ovarian and lung cancer cells [26, 27, 28].

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