From the article:
“Further testing showed that HT-0411 doesn’t directly activate CREB. It does so indirectly by inhibiting the enzyme monoamine oxidase B, which modulates dopamine and ultimately leads to CREB-mediated gene expression.”
MAOb inhibitors have been around for a long time. Selegiline (Deprenyl) is popular among the nootropic crowd:
I have taken Selegiline, though not before studying. All I could sense was stimulation, and since I don’t personally care for the type of stimulation offered by MAOIs, I didn’t continue to take it.