CONCLUSIONS:
We replicated the finding that cognitive remediation increases left lateral prefrontal activation during a working memory task in patients with schizophrenia, suggesting this may be an important neural target for these types of interventions.
IS Ramsay, TM Nienow, MP Marggraf and AW MacDonald,
The British journal of psychiatry : the journal of mental science , Mar 2017
BackgroundPatients with schizophrenia have shown cognitive improvements following cognitive remediation, but the neuroplastic changes that support these processes are not fully understood.AimsTo use a triple-blind, placebo-controlled trial to examine neural activation before and after cognitive remediation or a computer skills training (CST) placebo (trial registration: NCT00995553)).MethodTwenty-seven participants underwent functional magnetic resonance imaging before and after being randomised to either cognitive remediation intervention or CST. Participants completed two variants of the N-back task during scanning and were assessed on measures of cognition, functional capacity, community functioning and symptoms.ResultsWe observed a group Ă— time interaction in the left prefrontal cortex, wherein the cognitive remediation group showed increased activation. These changes correlated with improved task accuracy within the cognitive remediation group, whereas there was no relationship between changes in activation in untrained cognitive measures. Significant changes were not observed in other hypothesised areas for the cognitive remediation group.ConclusionsWe replicated the finding that cognitive remediation increases left lateral prefrontal activation during a working memory task in patients with schizophrenia, suggesting this may be an important neural target for these types of interventions.
3 Likes
How many yearal it wil be taking to be for the time peroid of the human being. …
Andrey
February 6, 2017, 12:18pm
3
For once, I really don’t understand your English far cry
1 Like
I mean eatablishing it on human life
Andrey
February 6, 2017, 12:24pm
5
You mean, how long does one have to follow a cognitive remediation regimen ??
Understood now andrey my english and sz sucks…
Then they go for clinikal teasts…!!or trails…
I guess this study offers hope for the future of sz treatments. Maybe it is reconcilable brain damage after all
