A novel research tool developed by researchers from the Institute of Psychiatry, Psychology & Neuroscience (IoPPN) at King’s College London has identified a link between the negative symptoms experienced by people with schizophrenia and adverse clinical outcomes.
Negative symptoms can include poor motivation, poor eye contact and a reduction in speech and activity. As a result, people with schizophrenia often appear emotionless, flat and apathetic. These contrast with positive symptoms - psychotic behaviours not seen in healthy people, such as delusions or hallucinations.
Published today in BMJ Open, the study is the largest- ever to investigate a relationship between negative symptoms and clinical outcomes, drawing from a sample of more than 7,500 patients.
Researchers used the Clinical Record Interactive Search (CRIS) application, a text-mining tool, to analyse anonymised patient data on negative symptoms from the South London and Maudsley NHS Foundation Trust (SLaM) Biomedical Research Centre (BRC) Case Register.
Natural Language Processing (NLP) was used to detect statements within the clinical records which determined references to specified negative symptoms. 10 negative symptoms were identified, including poor motivation, blunted or flattened mood, poor eye contact, emotional withdrawal, poor rapport, social withdrawal, poverty of speech (excessively short speech with minimal elaborations), inability to speak, apathy and concrete thinking (the inability to think in abstract terms).
They found that 41 per cent of patients showed the presence of two or more negative symptoms. Negative symptoms across the sample were associated with an increased likelihood of hospital admission, longer duration of admission and an increased likelihood of re-admission following discharge from hospital.
Patients with two or more negative symptoms were 24 per cent more likely to have been admitted to hospital. In addition, each of their admissions were, on average, an extra 21 days in duration and, when discharged, these individuals had a 58 per cent higher risk of re-admission within 12 months.