Minocycline augmentation therapy in schizophrenia: a systematic review

SzAdmin · August 29, 2014, 6:30pm

THis looks like an interesting new therapy for schizophrenia coming down the pipe:

ncbi.nlm.nih.gov

Efficacy and tolerability of minocycline augmentation therapy in schizophrenia: a systematic review and meta-analysis of randomized controlled trials.

K Oya, T Kishi and N Iwata, Human psychopharmacology, Sep 2014

This study aimed to perform a comprehensive meta-analysis of minocycline augmentation therapy in patients with schizophrenia receiving antipsychotic agents.Data published up to 2 June 2014 were obtained from the PubMed, PsycINFO, Google Scholar, and Cochrane Library databases.We conducted a systematic review and meta-analysis of patient data from randomized controlled trials (RCTs) comparing minocycline with placebo. Relative risk (RR), standardized mean difference (SMD), and 95% confidence intervals were calculated.We included four RCTs. The total sample included 330 patients. Minocycline was superior to placebo for decreasing Positive and Negative Syndrome Scale (PANSS) total scores (SMD=0.70), PANSS negative subscale scores (SMD=0.86), and PANSS general subscale scores (SMD=-0.50) but was not different from placebo for PANSS positive subscale scores (SMD=0.26) and depressive symptoms (SMD=0.28). Minocycline was equivalent to placebo for all-cause discontinuation (RR=1.10), discontinuation due to inefficacy (RR=0.42), discontinuation due to adverse events (RR = 1.56), and discontinuation due to death (RR = 3.18). Minocycline was superior to placebo for extrapyramidal side-effect scores (SMD=0.32).Minocycline may improve the psychopathology of schizophrenia, especially the negative symptoms, and seems to be well tolerated.

And more on the drug:

Topic		Replies	Views
Adjunctive minocycline for schizophrenia: A meta-analysis of randomized controlled trials News	4	769	December 7, 2016
Systematic review and meta-analysis of the efficacy and safety of minocycline in schizophrenia News	2	670	February 10, 2017
Adjunctive minocycline for schizophrenia found beneficial News	4	734	November 13, 2017
Adjuvant therapy with minocycline for schizophrenia (The MINOS Trial): study protocol for a double-blind randomized placebo-controlled trial Medications	0	661	November 27, 2013
Minocycline add-on to Antipsychotics for the Treatment of Negative and Cognitive Symptoms in Schizophrenia (trial) News	2	626	September 21, 2016

Minocycline augmentation therapy in schizophrenia: a systematic review

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