ITI-007 people to present at Conference of the International Society for Bipolar Disorders

The presentations will be onMay 5 and 6, we may find out some more about the drug’s development and properties.

https://finance.yahoo.com/news/intra-cellular-therapies-present-19th-120000360.html

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Hopefully we’ll get a few more tidbits, did you hear about the new brain pathway which was discovered?

I didn’t post it because I don’t know how. Anyhow thanks for posting this.

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The new discovery is 4 cognitive deficit …

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No, I didn’t thanks for that link! It sounds very promising:

“Efforts to develop pharmaceuticals to address these deficits have so far been unsuccessful, but in our study we were able to enhance NMDAR function via D-serine by stimulating a7nAChRs with a drug that has been part of recent stage 3 clinical trials for schizophrenia,” said Philip G. Haydon, Ph.D., corresponding author on the paper"

I didn’t understand most of the science, but I liked that part :slight_smile:
Emphasis added is mine - wonder what drug it was???

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NaBen is the D amino oxidase inhibitor which means it reverses NMDA hypofunction via D-serine. However the a7nAChRs part doesnt sound like NaBen, maybe they are talking about encenicline which was an a7nicotinc agonist which failed back in 2015-'16. I think they might still be pursuing encenicline in other indications, when it failed I was so disappointed.

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