Increased Intrinsic Brain Activity in the Striatum Reflects Symptom Dimensions in Schizophrenia.
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Striatal dysfunction is thought to be a fundamental element in schizophrenia . Especially, dopamine transmission in the striatum is increased during prodromal and psychotic states. Such elevated dopamine levels correlate with positive disease symptoms and antidopaminergic drugs reduce these symptoms in most patients.
During psychosis, coherent intrinsic activity of the striatum was increased in the dorsal part and correlated with positive symptoms such as delusion and hallucination. In psychotic remission of the same patients, activity of the ventral striatum was increased and correlated with negative symptoms such as emotional withdrawal and blunted affect.
I wonder what this means and if it can be treated.
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