Impact of Chronic Cannabis Use on Auditory Mismatch Negativity Generation in Schizophrenia Patients

firemonkey · March 6, 2018, 12:00pm

ncbi.nlm.nih.gov

Impact of Chronic Cannabis Use on Auditory Mismatch Negativity Generation in Schizophrenia Patients.

P Roser, EM Pichler, B Habermeyer, W Kawohl and G Juckel, Pharmacopsychiatry, Mar 2018 05

Cannabis use disorders (CUD) are highly prevalent among patients with schizophrenia (SCZ). Deficient mismatch negativity (MMN) generation is a characteristic finding in SCZ patients and cannabis users. This study therefore examined the effects of CUD on MMN generation in SCZ patients.Twenty SCZ - CUD patients, 21 SCZ+CUD patients, and 20 healthy controls (HC) were included in this study. MMN to frequency and duration deviants was elicited within an auditory oddball paradigm and recorded by 32 channel EEG.As expected, SCZ - CUD patients showed reduced frontocentral MMN amplitudes to duration deviants compared to HC. Interestingly, SCZ+CUD patients demonstrated greater MMN amplitudes to duration deviants compared to SCZ - CUD patients at central electrodes with no differences compared to HC.These results demonstrate that comorbid cannabis use in SCZ patients might be associated with superior cognitive functioning. It can be assumed that the association between cannabis use and better cognitive performance may be due to a subgroup of cognitively less impaired SCZ patients characterized by lower genetic vulnerability for psychosis.

It enhances cognitive performance. It worsens cognitive performance. So much conflicting information!

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Impact of Chronic Cannabis Use on Auditory Mismatch Negativity Generation in Schizophrenia Patients

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