I have two possible options... Clozapine vs abilify

Abilify is a drug primarily used in patients with milder forms of schizophrenia - being a partial dopamine agonist it could worsen psychosis.
Clozapine is a more effective medication, used for more severe or hard to treat medication resistant cases - but comes with a lot of side effects and weight gain usually

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This is great information! I will bear this in mind when making a decision, thank you very much for taking the time to reply!

I know someone who takes it. He showed me his test results where he had a low white blood cell count. He almost died when his appendix burst and I’m not sure it’s related. It’s difficult for him to get refills instantly as he has to go through this complex process, and then complained his doctor was trying to kill him because they wouldn’t give him the medication. It does make him calm, and much more normal seeming. He said Abilify never worked for him. He still has delusional beliefs on it, but can communicate better and seems to function more normally by taking his medication regularly and not using drugs. It wouldn’t be right for me, because I’ve responded fairly well to medications other than Seroquel and Geodon and since I’ve been on Abilify for so long it’s the one that works the best. I take a high dose of 30mgs each night, it helps me sleep usually. Lower doses don’t work as well, but my psychiatrist recently attempted to half the dose of Abilify so I could function better. I realized that perhaps there were other factors influencing my memory recall and attention. Adderall helps me with the worst cognitive symptoms, but it’s not a common option for people with schizophrenia as for some it can cause psychosis. I only got diagnosed with ADHD as an adult, and the stimulant medication has helped me with drive and focus.

On the flip side, Abilify is often prescribed for people with milder schizophrenia…but I was in the worst states of psychosis when I started Abilify and over years it has lessoned my symptoms. I was started on it as a teen. It prevents thoughts from becoming irrational. I feel like it allows me to think versus other anti-psychotics. I’m more productive on Abilify. It just takes a lot of time and patience. You have to take it regularly for several months to see an improvement.

They tried a bunch of other anti-psychotics on me, and since Abilify was brand new at the time–they tried it on me as a last resort and it worked amazingly well. I recall finally being able to sleep, it cured my insomnia and irrational psychosis almost instantly. When I finally agreed to take it, it did help. Clozapine is a higher risk medication, you need to be approved for it and take frequent blood tests to determine that it isn’t killing you. You need to monitor your white blood cells and not drink alcohol or use drugs like weed on it.

I’m not sure how clozapine works, but my friend with more severe ptsd and schizophrenia swears by it that it’s the only medication that works for him. I notice when he doesn’t take it he’s completely crazy though, so I don’t know how effective it is over time or long-term, how beneficial it would be to your recovery if you end up dependent on a medication that is so dangerous–for life. Once you’re on it, IDK how hard it is to get off it, I do know my friend said he experiences severe withdrawal like irritability and hostility.

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Thank you all, Considering that abilify is an agonist, and can make me worse I fear using that.

I feel this time around I could manage a weight gain side effect when considering clozapine, mum says she’ll weigh me every week and keep a close eye on it. Sedation I’m not sure but a night time dose could be the thing to consider. I’m meeting with my doctor on the 14th January so will ask his advice.

I’m going to ask to not have a major med change until the summer, or attest until after my exam. I’m considering leaving college, prioritising my degree and possibly looking for something safe, maybe I’m just not ready yet. But I don’t know if I should persist, but I nearly self harmed at the end of this term, I know I fought it but I was unsafe. I’m fluctuating between all sorts of states of mind, extreme anger, to extreme fear, I feel as if I’m going to explode. I happier now the living room is finished I have a safe haven in my home.

I’m just going to go back until this unit of my course is finished which is two weeks, I will see how I cope, if it’s too much, I won’t let myself break, I may go back better, we’re trying to rest my head but it’s not working just yet.

Thank you for your replies, they’re all so helpful, and I’m open to any more!
Take care,
Meg.

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